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《Journal of Bethune Medical Science》 2014-04
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Observation of the curative effect of piperazine ferulate combined with irbesartan in treatment of early diabetic nephropathy

LIANG Yi;Department of Nephrology,People’s Hospital of Xinyi;  
Objective To explore the effect of irbesartan and ferulic acid piperazine combined treatment of diabetic nephropathy. Methods One hundred and twenty-six patients with diabetic nephropathy were randomly divided into study group and the control group( n = 63,each),and all the patients received conventional treatment and the study group was given additional drugs of Eritrea irbesartan and ferulic acid piperazine,while patients in the control group was given irbesartan. The treatment effect,UAER,Scr,SBP,andβ2-MG of the two groups before and after treatment were observed and compared. Results After treatment the total efficacy rate of observation group was 92. 1%,higher than 76. 2% of control group( P 0. 05). Before treatment,levels of UAER,Scr and β2-MG of the two groups showed no significant difference( P 0. 05). After treatment,levels of UAER,Scr and β2-MG of the two groups showed a significant decrease( P 0. 01). Levels of UAER and β2-MG of the observation group decreased more obviously than that of control group( P 0. 01). Conclusion The two drugs used in combination can significantly improve the patient's symptoms,renal function and prognosis.
【CateGory Index】: R587.2;R692
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