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《Journal of Inner Mongolia University of Science and Technology》 2017-01
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Palindrome distribution in the C. elegans genome

FENG Fen;LIU Guo-qing;Mathematics,Physics and Biological Engineering School,Inner Mongolia University of Science and Technology;The Institute of Bioengineering and Technology,Inner Mongolia University of Science and Technology;  
Genomic palindromes can not only act as gene regulatory motifs but also cause diseases by inducing genome instability. In the present study,palindromes in the Caenorhabditis elegans genome was identified,the overall distribution pattern of palindromes across the genome was uncovered,and then the possible functions of palindromes in light of the palindrome distribution and abundance in the genome were discussed. Results show that:( 1) Among the different kinds of genomic regions such as CDS,introns and intergenic sequences,palindrome abundance decreases in the order of introns,intergenic sequences,and CDS;( 2) As the palindrome size increases,its relative abundance becomes larger,suggesting the distinct selection on the usage of different-sized palindromes in the genome;( 3)The GC content of palindromes tends to decrease with increasing palindrome size,and different genomic regions including CDS,intergenic sequences,and introns show distinct palindrome GC content;( 4) Palindromes are enriched in transcription factor binding sites,and there are obvious palindrome motif in motif of TFBS,suggesting the potential role of palindromes in gene transcription.
【Fund】: 内蒙高校青年科技英才支持计划资助项目(NJYT-14-B10)
【CateGory Index】: Q78
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