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《Journal of Baotou Medical College》 2014-01
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A Correlation Study between Plasma CTGF Level and Acute Atherosclerotic Cerebral Infarction

ZENG Qingxin;ZHANG Kun;WANG Shaobin;WANG Dong;Department of Neurology,Baogang Hospital;Department of pathophysiology,Baotou Medical College;  
Objective: To investigate the correlation between plasma connective tissue growth factor( CTGF) level and acute atherosclerotic cerebral infarction. Methods: Thirty patients with acute atherosclerotic cerebral infarction and 30 normal controls were recruited from our hospital. All subjects were given an ultrasonic examination of carotid artery to detect the intima- media thickness( IMT). Peripheral blood was taken and plasma concentration of CTGF was tested by enzyme linked immunosorbent assay( ELISA). Results: The level of plasma CTGF in patients( 1. 47 ± 0. 21) μg / L was significantly higher than in controls( 0. 73 ± 0. 25) μg / L. The results of ultrasonic examination showed that IMT of carotid artery in patients( 1. 20 ± 0. 21) mm was also significantly higher than in controls( 0. 91 ± 0. 25) mm. The plasma CTGF level was significantly increased in patients with carotid plagues( 1. 40 ± 0. 31) μg / L compared with the subjects without plagues( 0. 87 ± 0. 39) μg / L. Conclusion: The increased plasma CTGF level is related to the thickness of carotid artery intima and the formation of plagues. CTGF plays an important role in the development of acute atherosclerotic cerebral infarction.
【CateGory Index】: R743.3
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