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《Journal of Baotou Medical College》 2018-09
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Effects of Bawei Chenxiang powder on expression of ICAM-1 in rats with focal cerebral ischemia

WANG Ruifang;HE Jingbo;WANG Yuanting;ZHANG Ning;HU Juan;AN Mengmeng;SHEN Yue;WU Haijun;YANG Yumei;CAO Lixia;LI Yueling;Baotou Medical College;  
Objective: To investigate the expression of intercellular adhesion molecule-1( ICAM-1) in different phases of brain after focal cerebral ischemia in SD rats and the effect of Bawei Chenxiang powder on it. Methods: 360 male SD rats were randomly divided into sham operation group,model group,high-dose group of Bawei Chenxiang powder( 0. 8 g/kg),middle-dose group of Bawei Chenxiang powder( 0. 4 g/kg) and Bawei incense scattered small dose group( 0. 2 g/kg).Each group was randomly divided into 1 h group,6 h group,12 h group,24 h group,72 h group,120 h group and 6 other phase groups. Each group had 12 rats. The modified middle cerebral artery( MCAO) embolization model was established by a modified Zea Longa method. Real-time fluorescence quantitative PCR was used to detect the expression of ICAM-1 at different phases in rats with focal cerebral ischemia after intervention of Bawei Chenxiang Powder. The effect of Bawei Chenxiang powder on the mRNA expression of ICAM-1 in brain tissue of rats with cerebral ischemia at different time points was analyzed. Results: Compared with the sham-operated group,the neurological function scores of the model group were significantly increased,and the model group scores were all more than 2 points,which proved the success of the model. ICAM-1 began to increase 1 hour after cerebral ischemic injury,reached a peak at 24 hours,and gradually decreased after 72 hours( P 0. 05); the expression of ICAM-1 in Bawei Chenxiang Powder was significantly lower in each dose group than in the model group.( P 0. 05),but still higher than the sham group. Conclusion: Bawei Chenxiang Powder can reduce the ischemic injury of brain tissue by reducing the expression of vascular cell adhesion molecule-1( ICAM-1) in the brain tissue of rats with focal cerebral ischemia to play a role in the treatment of focal cerebral ischemic injury.
【Fund】: 内蒙古教育厅项目(NJZY16205);; 国家自然科学基金(81160560);; 内蒙古自治区科学技术协会项目(20160306);; 内蒙古自然科学基金(2016MS08102 2016MS0807)
【CateGory Index】: R285.5
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