Effects of fluvastatin on myocardial fibrosis in rats with acute myocardial infarction
SU Zhenggang;WU Zhenli;TANG Jieying;YAN Dong;Baotou Medical College;People's Hospital Cadre Health Care Institute in Inner Mongolia Autonomous Region;General Hospital of Staff and workers of Anyang Iron and Steel Group in Anyang City;The Fifth People's Hospital of Anyang City;
Objective: To observe the expression of Transforming Growth Factor( TGF-β1) after myocardial infarction in rats with SD,and to compare the expression of TGF-β1 after fluvastatin intervention,so as to find a possible intervention for myocardial fibrosis after myocardial infarction. Methods: 60 male SD rats were randomly divided into 3 groups. The acute myocardial infarction model was made in the control group( AMI control group,n = 20) and the intervention group( AMI intervention group,n = 20),and the other group was sham operated group( sham group,n = 20). After 4 weeks,the rats were killed and the expression of TGF-β1 protein was detected by Mason staining and Western blot( Western-blot). Results: CVF in sham group was lower than that of AMI intervention group(P 0. 05),and CVF in AMI intervention group was lower than that of AMI control group( P 0. 05). The expression of TGF-β1 in sham group was lower than that of AMI intervention group( P 0. 05),and the expression of TGF-β1 in AMI intervention group was lower than that of AMI control group( P 0. 05). Conclusion: After acute myocardial infarction,myocardial fibrosis is obvious,and the expression of TGF-β1 increased. After the intervention of fluvastatin,myocardial fibrosis was reduced and the expression of TGF-β1 reduced. It suggests that statins have effects on anti-myocardial fibrosis,and its mechanism may be related to the inhibition of the expression of TGF-β1.
【CateGory Index】： R542.2