EFFECTS OF SUBSTANCE P ON THE CONTRACTION OF THE GALLBLADDER OF GUINEA-PIG INDUCED BY ACETYLCHOLINE AND DOPAMINE
Huang Lingsun, et al (Department of Physiology, Binzhou Medical College)
The purpose of this study was to observe the effects of substance P (SP) on the contraction of gallbladder of guinea-pig induced by acetylcholine (Ach) and dopamine (DA) in vitro. The results were as follows: (1)SP could stimulate contraction of gallbladder strip in a doseresponse way. (2)SP could enhance the gallbladder contraction induced by Ach and DA. Our results suggest that SP as an excitatory transmitter and/or modulater might regulate the gallbladder motility with Ach and DA.