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《Journal of Binzhou Medical University》 2017-01
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Effect of Weiweikang on the expression of wild-type p53 and Bax in gastric mucosal in rats with chronic atrophic gastritis

LIN Haiyan;YU Jianing;ZHAI Jiali;ZHAO Yan;College of Combining Traditional Chinese and Western Medicine,Binzhou Medical University;Department of Two Gland Surgery,Yantai Affiliated Hospital of Binzhou Medical University;  
Objective To observe the mechanism of Weiweikang treating chronic atrophic gastritis.Methods Eighty-fourrats were randomly divided into normal group and model group.The rats in model group were modeled by compound methods.After the success of the model,the remaining 60 rats in model group were devided into model group,Weiweikang low dose group,Weiweikang medium dose group,Weiweikang high dose group and western medicine group.The rats in all groups were all treated with the corresponding drug by stomach way.After 30 days,we did the routine pathology and measured the expression of wild-type p53 and Bax by the technique of Immunohistochemical method.Results Compared with the normal group,the expression of wild-type p53 and Bax in gastric mucosal in model group significantly decreased(P0.05).After treating with drugs,the expression of wild-type p53 and Bax in gastric mucosal in each treatment group significantly increased(P0.05).The expression of wild-type p53 and Bax in Weiweikang high dose group increased most obviously(P0.05).Conclusion Curative effect in Weiweikang high dose group is best.The possible mechanism of Weiweikang treating chronic atrophic gastritis is promoting cell apoptosis and inhibitting cell proliferation to prevent gastric mucosal canceration.
【Fund】: 国家自然科学基金(81273724);; 山东省自然科学基金(ZR2014HL094);; 山东省中医药科技发展计划(2013-249)
【CateGory Index】: R285.5
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1 LIN Hai-yan;YU Jia-ning;ZHAI Jia-li;ZHAO Yan;Institute Combining Traditional Chinese and Western Medicine of Binzhou Medical University;Two Gland Surgery of Yantai Affiliated Hospital of Binzhou Medical University;;Effect of Weiweikang on the content of IL-6 and IL-10 in serum and the expression of NF-Kappa B in gastric mucosal in rats with chronic atrophic gastritis[J];中国中西医结合消化杂志;2016-12
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