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《Journal of Binzhou Medical University》 2017-01
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Expression of MicroRNA-199a-5p in gastric cancer and its significance

LI Yanbin;HU Baoguang;LI Yuming;TIAN Xiaokun;ZHANG MingKai;GE Pengbo;Department of Gastrointestinal Surgery,Binzhou Medical University Hospital;  
Ojective To investigate the role of MicroRNA-199a-5p in the occurrence,development and metastasis of gastric cancer.Methods The Real-time RT-PCR assay was used to examine the MicroRNA-199a-5p expression in the tumor and its adjacent normal tissues,and the relationship between the expression level and the clinical characteristics of gastric cancer was analyzed.Results The level of MicroRNA-199a-5p expression in tumor tissue(1.15)was significantly lower than that in normal gastric mucosa(2.84)(P0.05),and its expression was related to tumor size,stage,degree of differentiation,lymph node metastasis.Conclusion MicroRNA-199a-5p low expression has an important role in the occurrence,development,invasion and metastasis of gastric cancer.
【Fund】: 2015年山东省医药卫生科技发展计划(2015WSB30018);; 滨州医学院校级科研计划(BY2014KYQD37)
【CateGory Index】: R735.2
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