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《Journal of Binzhou Medical University》 2017-01
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Significance of the tumor associated macrophages in invasive ductal breast carcinoma

LI Lingling;WANG Xia;Department of Pathology,Binzhou Medical University;Department of Pathology,Wudi People's Hospital;  
Objective To investigate the expression of tumor associated macrophages(TAMS)in breast invasive ductal carcinoma and its clinical significance.Methods Using immuno-histochemical Evision method,we detected the infiltration of tumor associated macrophages in 80 cases of invasive ductal breast carcinoma(38cases with lymph node metastasis,42 cases without lymph node metastasis)and normal breast tissue adjacent to carcinoma(30cases)marked by CD68,and CD163,and analyzed the relationship between the TAMS infiltration and clinical pathological factors of breast cancer.Results The positive expression rates of CD68 and CD163in breast invasive ductal carcinoma were 63.75% and 53.75%,respectively.There was statistical significance in expression difference among lymph node metastasis group(positive rate 73.68% and 73.68%),no lymph node metastasis group(52.38% and 45.23%),and normal tissue adjacent to carcinoma group(13.33% and 13.33%).TAMS was closely related to histological grade and clinical staging of breast cancer(P0.05).The expression of CD68 had a positive correlation with the expression of CD163(r=0.581,P0.05).Conclusion Abnormally high infiltration of TAMS is adverse to the prognosis of patients with breast cancer.TAMS expression detection can be used to estimate the prognosis of breast cancer invasion and metastasis and clinical indicators.
【CateGory Index】: R737.9
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