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《Journal of Binzhou Medical University》 2017-01
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The effects of edaravone on the plasma levels of p53 and caspase-3 in patients with acute cerebral infarction

GAO Juan;LIU Qingxin;College of Clinical Medicine,Binzhou Medical University;Department of Neurology,Binzhou Medical University Hospital;  
Objective To analyse the effects of edaravone injection on the plasma levels of p53 and caspase-3in patients with acute cerebral infarction and on the influence of nerve function defect,and to explore the mechanism of cerebral protection of edaravone.Methods A total of 80 patients with acute cerebral infarction were selected who met the entry criteria and were admitted to the Department of Neurology of our hospital from August 2015 to August 2016,and they were randomly divided into experimental group and control group,with 40 cases in each group.The control group were given routine treatment and the experimental group were given edaravone injection on the basis of control group.We used ELISA method to measure the levels of plasma p53 and caspase-3before the treatment(within 48 hours of onset)and on the seventh day of treatment,and we assessed the NIHSS scores before treatment,on the seventh and fourteenth days of the treatment.Results There was no difference of the levels of plasma p53 and caspase-3between control group and experimental group before the treatment.The levels of plasma p53 and caspase-3of control group and experimental group after the treatment both decreased than before the treatment,and the difference was statistically significant(P0.05);the decrease levels of plasma p53 and caspase-3in the treatment group were significantly higher than those in the control group,the difference was statistically significant(p0.05);the NIHSS scores in both group decreased after the treatment than before the treatment and the difference was statistically significant(P0.05);the NIHSS scores in the experiment group were lower than those in the control group after the treatment with siginificant difference(P0.05).Conclusion Edaravone significantly improved nerve function defect symptoms and decreased the levels of p53 and caspase-3in ischemic stroke patients,which indicated that edaravone has neuroprotective effects and that the mechanism may be related to anti-apoptosis.
【CateGory Index】: R743.33
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