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《Journal of Binzhou Medical University》 2017-01
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The effects of edaravone on the plasma levels of p53 and caspase-3 in patients with acute cerebral infarction

GAO Juan;LIU Qingxin;College of Clinical Medicine,Binzhou Medical University;Department of Neurology,Binzhou Medical University Hospital;  
Objective To analyse the effects of edaravone injection on the plasma levels of p53 and caspase-3in patients with acute cerebral infarction and on the influence of nerve function defect,and to explore the mechanism of cerebral protection of edaravone.Methods A total of 80 patients with acute cerebral infarction were selected who met the entry criteria and were admitted to the Department of Neurology of our hospital from August 2015 to August 2016,and they were randomly divided into experimental group and control group,with 40 cases in each group.The control group were given routine treatment and the experimental group were given edaravone injection on the basis of control group.We used ELISA method to measure the levels of plasma p53 and caspase-3before the treatment(within 48 hours of onset)and on the seventh day of treatment,and we assessed the NIHSS scores before treatment,on the seventh and fourteenth days of the treatment.Results There was no difference of the levels of plasma p53 and caspase-3between control group and experimental group before the treatment.The levels of plasma p53 and caspase-3of control group and experimental group after the treatment both decreased than before the treatment,and the difference was statistically significant(P0.05);the decrease levels of plasma p53 and caspase-3in the treatment group were significantly higher than those in the control group,the difference was statistically significant(p0.05);the NIHSS scores in both group decreased after the treatment than before the treatment and the difference was statistically significant(P0.05);the NIHSS scores in the experiment group were lower than those in the control group after the treatment with siginificant difference(P0.05).Conclusion Edaravone significantly improved nerve function defect symptoms and decreased the levels of p53 and caspase-3in ischemic stroke patients,which indicated that edaravone has neuroprotective effects and that the mechanism may be related to anti-apoptosis.
【CateGory Index】: R743.33
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 Chen Chuanguo,Wang Juan,Fei Shizao,et alDepartment of Emergency,Wuhu No.2 People's Hospital,Wuhu 241000,China;Meta-analysis on the clinical effects of edaravone in the treatment of acute cerebral infarction in China[J];安徽医学;2013-01
2 ZHOU Qiu-hua~*,WAN Chun-xiao,LU Xiao-jie.* Department of Pharmacy,Wuxi No.2 People's Hospital,Affiliated to Nanjing Medical University,Wuxi 214000,China;Clinical study in effect of edaravone on free radical scavenging in patients with acute cerebral infarction[J];中华老年医学杂志;2010-12
【Co-citations】
Chinese Journal Full-text Database 4 Hits
1 Song Naiguang;Sun Jingjing;Zhang Yaolong;Sun Caiyue;Xue Jian;Li Haipeng;He Yonggui;Xi Jinkun;Zhang Guobin;Department of Emergency,the Union Hospital of Tangshan City;;Effects of hyperbaric oxygen combined with edaravone on AQP9 expression andbrain edema in cerebral infarction rats[J];中国实用神经疾病杂志;2016-24
2 ;Randomized controlled trials of Edaravone plus the Shuxuetong injection for acute cerebral infarction[J];中医临床研究;2016-01
3 PENG Yongjun;YU Nengwei;Dept.of Neurology,Panzhihua Centeral Hospital;Dept.of Neurology,The People's Hospital of Sichuan Province;;Effect of Fluoxetine on Motor and Cognitive Functions Deficits in Acute Cerebral Infarction Patients[J];武汉大学学报(医学版);2015-03
4 ZHANG Cong-gao,ZHOU Yi-feng,BAI Qiu-qin.Department of Neurology,Chuzhou Clinical College of Anhui Medical University,the First People's Hospital of Chuzhou,Chuzhou 239000,AnHui,China;Clinical Study of Edaravone-Defibrase Combination on Acute Brain Infarction[J];中华全科医学;2012-06
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 SUN Li-hua,HAN Le-feng (Dept of Neurology,Hospital of Xishan Coal and Electricity Group Co.,Taiyuan 030053,China);Clinical efficacy of edaravone and ozagrel in the treatment of progressive stroke[J];山西医科大学学报;2010-02
2 CHEN Hai-ying(Neurology Department,the Third Hospital in Xiamen Xiamen 361100,China);Effects of edaravone on acute cerebral infarction[J];海南医学院学报;2009-10
3 ZHAO Lian-dong,JIN Guan-rong XU Han-rong(the second people's hospital of Huaian,Jiangsu Huaian 223002,China);Effects of edaravone on cerebral Caspase-3 protein expression after transient focal cerebral ischemia and reperfusion in rats[J];内科;2006-01
4 YANG Zheng,WU Yu lin ( Department of Physiology,China Pharmaceutical University,Nanjing 210009, China );Edaravone,an ethical brain protecting agent for acute cerebral infarction[J];中国新药杂志;2002-12
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