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《Journal of Binzhou Medical University》 2017-06
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The effect of nano-chitosan on the spleen function of rats

XIA Zhengdong;Department of Pathology,Jianhu Third People's Hospital;  
Objective To investigate the effect of nano-chitosan on the spleen function of rats.Methods Forty common SD rats were randomly divided into two groups:nano-chitosan group and normal saline group.Each group was administrated with drugs by caudal vein.We continued the administration for 7 days,and then killed the rats.We cultured the spleen cells and Human gastric carcinoma SGC-7901 cells at different ratios and detected the spleen index and the activity of the cytotoxic T lymphocytes by LDH-Cytotoxicity Assay Kit.Results Among the groups of mixed culture cells at different ratios,the nano-chitosan group showed higher cytotoxic activity.Compared to the normal saline group,there was statistically significant difference(P0.05).Conclusion The nano-chitosan can strengthen the immune function of spleen cytotoxic T cells of rats and there is a close relation between them.
【CateGory Index】: R392
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