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Preparation and Analysis of Solid Dispersion Systems of Usolic Acid

CHEN Wu,ZOU Sheng-qin (Bioengineering Research Institute of Yichun University,Key Laboratory of Province for Research on Active Ingredients in Natural Medicines,Yichun Jiangxi 336000,China)  
To enhance the dissolution rate of ursolic acid(UA) from its preparation,solid dispersion systems of UA in PVP-K30 were prepared at various weight ratios by co-evaporation of drug and PVP-K30 ethanol solution.The HPLC method were established to measure its external dissolusion rate.IR and UV spectral analysis were used to describe the status of drug in carriers.The result shows that HPLC method is accurate and reliable,and no interference occurs from carriers.The solid dispersion system in PVP-K30 can improve well the dissolution rate of ursolic acid.
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