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《Journal of Jiangxi Normal University(Natural Science Edition)》 2017-06
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The Enzymatic Synthesis of Castanospermine Derivatives

PENG Ren;YAO Qingwen;HONG Binwen;College of Life Science,Jiangxi Normal University;  
Castanospermine holds potential in the regulation of plant growth and the treatment of inflammatory disorder,viral infection,immunosuppressive deficiency and tumor metastasis. Some derivatives of castanospermine are more active than castanospermine itself in the inhibition of HIV and HCV. Enzymatic synthesis of castanospermine derivatives in organic solvent is studied by systematic trials of various parameters and 6-O-butanoyl castanospermine is purified. The synthesis of castanospermine derivatives by Lipozyme RM IM at 30 ℃ for 60 min in THF gives the best conditions,in which conversion rate of castanospermine is 84. 3% and yield rate of 6-O-butanoyl castanospermine is 39. 2%. The purified 6-O-butanoyl castanospermine has the same retention time as the standard in HPLC.
【Fund】: 国家自然科学基金(31360216);; 功能有机小分子教育部重点实验室开放课题(KLFS-KF-201226)资助项目
【CateGory Index】: Q814
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