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《JOURNAL OF CHENGDE MEDICAL COLLEGE》 2000-03
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THE CELLULAR GROW INDUCED CAPABILITY OF STAPHYLOCOCOAL ENTEROTOXIN A

HT5SS][KH2D][WT5BZ]WANG Ying,et al [WT5BX](Chengde Medical College,Hebei Chengde 067000,China)[KH2D][WT5HZ]  
Objective:To observe the cellular grow induced capability and antineplastic of staphylococcal enterotoxin A.Methods:In method with MTT.Results:The Purified SEA showed an increasing capability on BALA/C of spleenocyte in mice at dosage of 10 -12 ~10 -5 g/ml concentrations in vitro and in dose dependent manner.The SEA at 10 -7 ~10 -5 g/ml had more effect than PHA at optimum dose (25μg/ml).When E/T was at 5~20∶1,the activated spleenocyte BALB/C of mice by 10 -5 g/ml SEA for 48hr had more effect than NK in killing Yac 1 cell,but no marked increase in B 16 cell.Conclusion:Staphylococcal enterotoxin A has the better cellular grow induced capability,so that the capability of superantigen might be used in the anti tumor biological therapeutically rfficiency.
【CateGory Index】: R378.11
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