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《Journal of Chengde Medical College》 2004-01
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CHEN Xiang-qing,WANG Qin-mao,FANG Hua-wu,et al (Dept.Of Pharmacy,Anhui Provinical Hospital,Anhui Hefei 230001,China)  
Objectuve:To study the protective effects of total glucosides of paeony (TGP) and extract from Angelica Sinensis (EAS) on experimental immunological liver injury.Method:Mouse immunological liver injury was induced by BCG and LPS.Result:The decrease of ALT,AST,ALP and the increase of GSH in serum,which were caused by BCG and LPS,could be antagonised by TGP and EAS.The hepato-cellular degeneration and necrosis induced by BCG and LPS could also be diminished.The optimal dosage is TGP(200 mg·kg -1 ·d -1 ,7d,ig) plus EAS (153.4g·kg -1 ·d -1 ,7d,ig).Couclusion:Pre-treatment with TGP and EAS moderately prevents the liver damage induced by BCG and LPS. [
【CateGory Index】: R285
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