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《Journal of Chengde Medical College》 2005-01
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THE EFFECTS OF EMP ON THE EXPRESSION OF CREB AND NNOS PROTEININ HIPPOCAMPUS OF RATS

LI Yu-hong, ZHAO Xiang-yang, WANG De-wen (Department of Pathology, Chengde Medical College, Hebei Chengde 067000, China)  
Objective: To explore the effects of EMP on the expression of CREB and nNOS in hippocampus in rats.Methods:Western blotting and immunohistochemistry staining were employed to detect the expression of CREB and nNOS protein in hippocampus before and after EMP exposure.Results:The CREB protein increased at 1h and reached the highest level at 6h after exposure. The expression of nNOS rised markedly at 1~6h after exposure.Conclusions:The changes of transcription factor CREB and nNOS, a key synthetase for reverse-messenger NO, may partly contributed to the effect of EMP on central nervous system.
【CateGory Index】: R361
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