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《Journal of Chengde Medical College》 2006-01
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QUANTITATIVE ANALYSIS ON MORPHOLOGICAL CHANGES OF MITOCHONDRIA IN HIPPOCAMPAL NEURONS OF ISCHEMIA REPERFUSION RATS

ZHANG Lei,MI Shu-bin,ZHAO Shu-min(Chengde Medical College,Hebei Chengde 067000;China)  
Objective:To observe the morphological changes of mitochondria in hippocampal neurons of ischemia reperfusion rats.Methods:The ischemia reperfusion rats model were made by ligating the common carotid artery,and the rats were divided into I,II,III groups according to the reperfusion time.The ultrastructural changes of mitochondria in hippocampal neurons were observed with transmission electron microscopy and the morphological changes of mitochondria were analyzed by Leica Qwin image analysis system.Results:The ultrustructure of the mitochondria in the 3 reperfusion groups were observed obvious damages,and the damages in reperfusion II group were more severe than in I,III group.In the ischemia reperfusion II,III group,the volume density,numerical density,specific surface and cristac membrane density of mitochondria decreased obviously and the average volume,sectional area increased remarkably compared with sham-operation group(P0.05).In ischemia reperfusion I group,only the average volume and sectional area increased.Conclusions:Ischemia reperfusion can damage the morphosis of mitochondria in hippocampal neurons,and the damages are concerned with the reperfusion time.
【CateGory Index】: R741
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