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《Journal of Chengde Medical College》 2006-01
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STUDY ON THE EXPRESSION OF PCNA AND BFGF IN CA_3 AREA OF HIPPOCAMPUS AT DIFFERENT POSTNATAL GROWTH STAGE IN RATS

DU Jin-kai,PANG Xiao-jing,GAO Fu-lu,et al(Chengde Medical College,Hebei Chengde 067000,China)  
Objective:By studying on the expression of PCNA and bFGF in CA_3 area of hippocampus to make out the developmental law of hippocampus.Methods: The brain of rats were taken out at postnatal d1,d2,d3,d5,d10,d20,d30 respectively and fixed with 10% formalin,SP immunohistochemistry was used in this study to observe the expression of PCNA,bFGF in CA_3 area of hippocampus.Results: The PCNA expression in CA_3 area of hippocampus was the most obvious at postnatal d2,neurons in multiform layer proliferated the most,multiform layer took second place and pyramidal layer the least.The PCNA expression decreased gradually after postnatal d10 and basically ended at postnatal d30.bFGF positive cells were not observed in CA_3 area of hippocampus at postnatal d1-d2.The expression of bFGF reached the top at postnatal d3 and expressed the most in pyramidal layer,and became stable at postnatal d20.Conclusions: In the development of hippocampus,bFGF can stimulate the expression of PCNA.
【CateGory Index】: Q954.48
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