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《Journal of Chengde Medical College》 2006-01
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CLINICAL SIGNIFICANCE OF ENDOTHELIN-1,CALCITION GENE RELATED PEPTIDE, ALPHA TUMOR NECROSIS FACTOR AND INTERLEUKIN-8 IN PATIENTS WITH POSTHEPATITIC CIRRHOSIS

Shen Qun-xi,Zhu Ling-ling,Su Li,et al(The second hospital of shenzhen,guangdong 518035,China)  
Objective:To explore the clinical significance of Endothelin-1(ET-1),Calcition gene related peptide(CGRP),alpha tumor necrosis factor(TNF-α) and interleukin-8(IL-8) in patients with posthepatitic cirrhosis.Methods:68 patients with posthepatitic cirrhosis were collected and divided into A,B and C groups according to the Child-Pugh grade.Plasma ET-1,CGRP and serum TNF-α,IL-8 were detected by RIA methods and compared with control group(30 samples).Results: The levels of plasma ET1,CGRP and serum TNF-α,IL-8 were higher in patients with posthepatitic cirrhosis than those in control group(P0.01).There were significant differences of level of plasma ET-1,CGRP and serum TNF-α,IL-8 in the A,B and C group in patients(P0.01).Conclusion: ET-1、CGRP、TNF-α and IL-8 were important indexs which reflected the degree of liver damage and estimated the prognosis in posthepatitic cirrhosis.
【CateGory Index】: R575.2
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