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《Journal of Chengde Medical College》 2006-01
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A META-ANALYSIS OF INTERACTION BETWEEN GLUTATHIONE S-TRANSFERASE M1 NULL GENOTYPE,SMOKING AND ESOPHAGEAL CANCER

GUO Xin-hua,HUANG Zhi-gang,LIU Lingyun(The medical college of Hebei Engineering College,Hebei Handan 056029,China)  
Objective:To evaluate the associations and interaction between glutathione S-transferase M1(GSTM1) null genotype,smoking behaviour and the development of esophageal cancer by meta-analysis.Methods:Citations collected were stratified by smoking,and odds ratio was employed to evaluate the risk of esophageal cancer and GSTM1 status.To take into account the possibility of heterogeneity across the studies,a statistical test for heterogeneity was performed,and fixed or random effect meta-analysis model was used in terms of the result of heterogeneity test.And also the forest plots of meta-analysis were worked out.The gene-environment interaction of GSTM1 null genotype and smoking was assessed by case-only design.Results:A total of 560 cases and 743 controls from 5 studies was included.In smoking groups,the pooled OR was 1.523(1.099~2.109);in no smoking groups,the pooled OR was 0.933(0.469~1.855).An association between GSTM1 null genotype and smoking was found among cases.The pooled OR of interaction was 1.363(0.954~1.949).Conclusion:The smokers carring GSTM1 null genotype might be associated with the increased risk of esophageal cancer.There was a possible positive interaction between the effects of smoking and GSTM1 genotype on esophageal cancer risk.
【CateGory Index】: R735.1
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【Co-citations】
Chinese Journal Full-text Database 4 Hits
1 HUANG Zhigang,GUO Xinhua.Department of medical laboratory science,Heibei engineering university,Handan 056029,China;A Meta-analysis of Interaction between Glutathione S-transferase M1 Null Genotype,Smoking and Esophageal Cancer[J];Journal of Handan Medical College;2005-01
2 Wu Kusheng,Li Ke(Department of Preventive Medicine,Shantou University,Medical College,Shantou 515041,China);Meta-Analysis on the Relationship Between Genetic Polymorphism of Cytochrome P450 2E1 and the Susceptibility to Esophageal Cancer[J];Journal of Basic and Clinical Oncology;2006-01
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4 ZHANG Jiao,SHEN Xiao-bing School of Public Health,Southeast University,Nanjing 210009, China;Advances in Cytochrome P450 2E1 Genetic Polymorphism and Cancer Susceptibility[J];Journal of Labour Medicine;2004-06
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