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《Journal of Chengde Medical College》 2013-01
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EXPRESSION AND SIGNIFICANCE OF CD151 AND HEPARANASE IN GASTRIC CARCINOMA

LI Tao,LI Jian-tuan,QI Jie-min(Department of Pathology,Chengde Medical College,Hebei Chengde 067000,China)  
Objective:To investigate the expression and significance of CD151 and heparanase(HPA) in gastric carcinoma.Methods:SP immunohistochemical staining was used to detect the expression of CD151 and HPA in 80 cases gastric carcinoma and 50 cases normal gastric tissues.The relationships between CD151,HPA and biological behavior of gastric carcinoma and their correlations in gastric carcinoma were analyzed.Results:The positive rate of CD151 and HPA in gastric carcinoma were obviously higher than that of normal gastric tissue(P0.05).In gastric carcinoma,the positive expression of CD151 and HPA had relations with differentiation degree,TNM stage,lymph node metastasis and infiltration depth(P0.05).In gastric carcinoma,the expression of CD151 had positive correlation with HPA(r=0.469,P0.05).Conclusions: High expression of CD151 and HPA have close relations with growth,invasion and metastasis of gastric carcinoma.
【CateGory Index】: R735.2
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