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《Journal of Chengde Medical College》 2013-05
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EFFECTS OF SERICINE ON LIVER GLUCOGEN CONTENT IN TYPE 2 DIABETES MELLITUS RATS MODEL

ZHANG Yan;WANG Fu;QIAO Zhi-yan;Chengde Medical College;  
Objective:To observe the effects of sericine on blood glucose and liverglucogen in type2 diabetesmellitus rats model. Methods:60 male SD rats were randomly divided into 5 groups(n=12): normal control group,diabetes model group,sericine treatment group,positive control group and sericine prevention group. The type 2diabetes model rats were induced by continuous intraperitoneal injection of streptozotocin(STZ). After successfully establishing the diabetes animal model,the rats in diabetes model group were not given any more treatment,the rats in sericine treatment group were lavaged with sericine(2.4g/kg/d),the rats in positive control group were lavaged with metformin(55.33mg/kg/d). The rats in sericine prevention group were lavaged with sericine(2.4g/kg/d) before injecting STZ. Glucose oxidase was used to detect the fast blood glucose of rats in each group,PAS to detect the liver glucogen content. Results:Compared with rats in model group,the blood glucose of rats in sericine treatment group,positive control group and sericine prevention group significantly decreased(P 0.01); while the liver glucogen content increased obviously(P 0.01). Moreover,there had no obvious differences between sericine treatment group,sericine prevention group and positive control group(P 0.05). Conclusions: Sericine can significantly reduce the fast blood glucose of type 2 diabetes mellitus rats by increasing synthesis of liver glycogen,so to protect liver glycogen storage.
【Fund】: 河北省自然科学基金项目(H2012406018 H2013406096)
【CateGory Index】: R587.1
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