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《Journal of Chengde Medical College》 2013-05
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DYNAMIC CHANGES OF ENDOTHELIN-1 IN PLASMA OF CHRONIC HEART FAILURE RATS WITH MYOCARDIAL FIBROSIS

XIE Ya-qin;PENG Yu-juan;Chengde Medical College;  
Objective:To investigate the role of endothelin-1(ET-1) in development of myocardial fibrosis by observing the dynamic changes of ET-1 in plasma of chronic heart failure rats with myocardial fibrosis. Methods: The chronic heart failure(CHF) Wistar rats' model was established by partial ligation of abdominal aorta superior to renal artery,then the rats were randomly divided into 3 groups: heart failure 1d,7d and 14d group; at the same time,sham-operation group was taken as control. ELISA was used to detect the ET-1 level in plasma of rats in each group. Results:The ET-1 level in plasma of CHF rats was significantly higher than that of rats in sham-operation group(P 0.01). Moreover,the ET-1 level in plasma of CHF rats gradually increased with aggravation of myocardial fibrosis. Conclusions: ET-1 may participate in the development of pressure overload myocardial fibrosis; and the ET-1 level is closely related to the severity of chronic heart failure.
【CateGory Index】: R541.6
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