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《Journal of Chengde Medical College》 2014-01
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EFFECTS OF TSTDR ON TNF-α,IL-1β AND IL-6 EXPRESSION IN SPLEEN OF AA RATS

YANG Hui-jie;YAN Hao;TONG Ji-ming;Hebei Key Laboratory of Study and Exploitation of Traditional Chinese Medicine,Institute of Chinese Materia Medica;  
Objective:To study the effects of total saponins of Thladiantha dubia root(TSTDR) on spleen index and TNF-α,IL-1β,IL-6 expression in spleen of adjuvant arthritis(AA) rats.Methods:60 male SD rats were randomly divided into the following 6 groups with 10 rats in each group: normal control group,model group,TSTDR low dose(40 mg/kg/d) group,TSTDR middle dose(80 mg/kg/d) group,TSTDR high dose(160mg/kg/d) group and tripterygium glycoside group(12mg/kg/ d). The AA rats' model was established by injecting Freund's complete adjuvant into the plantar subcutaneous layer of right rear foot of rats,and then the rats in each drug group were lavaged with corresponding drugs for 21 days. The spleen index of rats in each group was calculated and immunohistochemical method was used to detect the TNF-α,IL-1β,IL-6 expression in spleen. Results:The spleen index of rats in TSTDR middle and high dose group were obviously lower than that of rats in model group(P 0.01,P0.05). The TNF-α,IL-1β,IL-6 expression in spleen of rats in each TSTDR group were all significantly lower than model group(P 0.01,P 0.05); Moreover,The TNF-α,IL-1β,IL-6 expression in spleen of rats in TSTDR middle and high dose group were significantly lower than TSTDR low dose group(P 0.01,P 0.05).Conclusions: Inhibition of TNF-α,IL-1β and IL-6 expression in spleen may be one of the mechanisms of TSTDR for treating AA.
【Fund】: 河北省自然科学基金项目(C200800655);; 河北省教育厅重大项目(ZD2010131)
【CateGory Index】: R285.5
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