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《Journal of Chengde Medical College》 2014-01
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ZHANG Jian-wei;ZHOU Feng-ju;SHEN Xing-bin;Department of Pathology,Affiliated Hospital of Chengde Medical College;  
Objective:To investigate the expression and clinical signifi cance of insulin-like growth factor-1(IGF-1) and insulin-like growth factor-1 receptor(IGF-1R) in pathogenesis of colorectal carcinomas. Methods:Immunohistochemical method was used to detect the expression of IGF-1 and IGF-1R protein in 50 cases colorectal carcinomas,20 cases colorectal adenoma and 20 cases normal colorectal mucosa. Results: From normal colorectal mucosa,colorectal adenoma to colorectal carcinomas,the expression of IGF-1 and IGF-1R protein gradually increased(P 0.01). In colorectal carcinomas,the expression of IGF-1 and IGF-1R had positive correlations(r=0.585,P 0.01).Conclusions:IGF-1 and IGF-1R may play an important role in development of colorectal carcinomas.
【CateGory Index】: R735.34
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