Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Chengde Medical College》 2014-01
Add to Favorite Get Latest Update

EXPRESSION AND SIGNIFICANCE OF IGF-1 AND IGF-1R IN COLORECTAL CARCINOMAS

ZHANG Jian-wei;ZHOU Feng-ju;SHEN Xing-bin;Department of Pathology,Affiliated Hospital of Chengde Medical College;  
Objective:To investigate the expression and clinical signifi cance of insulin-like growth factor-1(IGF-1) and insulin-like growth factor-1 receptor(IGF-1R) in pathogenesis of colorectal carcinomas. Methods:Immunohistochemical method was used to detect the expression of IGF-1 and IGF-1R protein in 50 cases colorectal carcinomas,20 cases colorectal adenoma and 20 cases normal colorectal mucosa. Results: From normal colorectal mucosa,colorectal adenoma to colorectal carcinomas,the expression of IGF-1 and IGF-1R protein gradually increased(P 0.01). In colorectal carcinomas,the expression of IGF-1 and IGF-1R had positive correlations(r=0.585,P 0.01).Conclusions:IGF-1 and IGF-1R may play an important role in development of colorectal carcinomas.
【CateGory Index】: R735.34
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 LI YanYan;HAO YunWei;JIANG Ying;HE FuChu;State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institution of Radiation Medicine, Academy of Military Medical Science;School of Life Sciences, Tsinghua University;;Cooperation of Liver Cells in the Metabolism Regulation of Bioactive Substances[J];Scientia Sinica(Vitae);2014-02
2 KANG Jun-peng;GUO Shu-qin;ZHANG Yun-liang;ZHU Chun-ying;ZHANG Ying-fu;LI Qian;HOU Yan-yan;Department of Endocrinology,Affiliated No.1 Central Hospital of Baoding,Chengde Medical College;Department of Oncology,Qinhuangdao First Hospital;;Expression and clinical significance of IGF-1R and IGFBP-3 in colorectal cancer[J];Chinese Journal of Clinical and Experimental Pathology;2014-02
3 PENG Qi-song;ZHANG Jun;LUO Guang-hua;Department of Laboratory Medicine,Nanjing Jiangning Hospital;Comprehensive Laboratory,the Third Affiliated Hospital,Soochow University;;Establishment of the real time PCR methods for detecting genes of insulin-like growth factors and their receptors[J];Chinese Journal of Clinical Laboratory Science;2014-05
4 GU Qunhao;HU Bo;ZHANG Xiaodong;JIAO Jianpeng;LIU Long;WEI Pinkang;Yueyang Hospital of Integrated Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine;The 206th Hospital of PLA;Shanghai Changzheng Hospital;Shanghai Changhai Hospital;;Clinical Observation on Xiaotan Sanjie Formula Combined With Chemotherapy for 32 Cases of Advanced Gastric Cancer[J];Journal of Traditional Chinese Medicine;2013-23
5 Zhang Lu;Yang Yaying;Huang Ziyang;Yi Yongfen;Teaching and Research Section of Pathology,College of Basic Medical Science,Molecular Medicine and Cancer Research Center,Chongqing Medical University;Department of Geriatrics,The First Affiliated Hospital of Chongqing Medical University;;Effect of Golgi α-mannosidase II expression inhibition by shRNA interference on invasive potential of human gastric cancer cell and its mechanism[J];Journal of Chongqing Medical University;2014-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved