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《Journal of Chengde Medical College》 2016-01
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STUDY ON TOXICITY AND REVERSIBILITY OF RHUBARB ON RATS' KIDNEY

ZHANG Teng;TONG Ji-ming;LIANG Ce;Hebei Key Laboratory of Research and Exploitation of Traditional Chinese Medicine,Institute of Chinese Materia Media,Chengde Medical College;  
Objective:To observe the toxicity and reversibility of long-term application of rhubarb on rats' kidney.Methods:40 SD rats were randomly divided into control group(n=10) and rhubarb group(n=30).The rats in rhubarb group were lavaged with rhubarb(2g/kg) for 60 days and then the rats were killed respectively 24 h after drug administration,30 d after drug withdrawal and60 d after drug withdrawal.The urea nitrogen and creatinine content in serum of rats were respectively detected;HE stain was used to observe the morphology of kidney.Results:During rhubarb administration,the rats were dispirited,the urine was dark red and defecated looser stools.The urea nitrogen content of rats in drug administration 60 d group was obviously higher than that of rats in control group(P0.05);but the creatinine content showed no obvious abnormal changes.The urea nitrogen and creatinine content of rats in drug withdrawal 30 d group and 60 d group had no statistically significant differences compared with rats in control group(P0.05).The morphological changes of rats' kidney in drug administration 60 d group:proximal tubule epithelial cells swelled,the renal tubular lumen became narrow,part of the epithelial cells shed;The glomerulus appeared no obvious pathological changes,such as atrophy,fibrosis and hypertrophy.The kidney of rats in drug withdrawal 30 d group and 60 d group showed no obvious pathological changes.Conclusions:Lavaging rhubarb(2g/kg) for 60 days has certain toxic effects on rats' kidney,but the injury is reversible and recover more fast
【Fund】: 河北省教育厅重大项目(2009301)
【CateGory Index】: R285.1
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