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《Journal of Chengde Medical College》 2016-01
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EFFECTS OF SCUTELLARIN ON EXPRESSION OF FAS AND FASL IN HUMAN TONGUE SQUAMOUS CARCINOMA TCA8113 CELLS

LI Ge;LI Jun-mei;GE Zhi-hua;The Affiliated Hospital of Chengde Medical College;  
Objective:To observe the effects of scutellarin on expression of Fas and FasL in human tongue squamous carcinoma Tca8113 cells.Methods:Human tongue squamous carcinoma Tca8113 cells were cultured in vitro and divided into control group and 3 scutellarin groups with different concentrations(80μg/ml,120μg/ml,160μg/ml).Immunocytochemical stain was used to detect the expression of Fas and FasL in human tongue squamous carcinoma Tca8113 cells.Results:The Fas and FasL expression level in Tca8113 cells of scutellarin groups was obviously higher than that of control group(P0.05);Moreover,with increasing of scutellarin concentrations,the Fas and FasL expression increased gradually(P0.05).Conclusions:Scutellarin may promote tumour cells apoptosis by upregulating the expression of Fas and FasL in human tongue squamous carcinoma Tca8113 cells.
【CateGory Index】: R285
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