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《Journal of Chengde Medical College》 2016-01
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AGGLUTINATION REACTION INDUCED BY PHYTOHEMAGGLUTININ AND ITS' EFFECTS ON COAGULATION SYSTEM

JIA Rui-yi;ZHANG Qing;DING Xiao-xu;Department of Respiratory Medicine,the Affiliated Hospital of Chengde Medical College;  
Objective:To explore the agglutination reaction induced by phytohemagglutinin(PHA) and it's effects on coagulation system.Methods:12 Wistar rats were randomly divided into experimental group and control group,which were injected PHA and 0.9%saline into caudal vein respectively.The agglutination of red blood cells in vitro and in vivo,hemolysis,the rats' general conditions and coagulation markers of rats were observed.Results:PHA could induce agglutination reaction and hemolysis in vitro and in vivo.The rats in experimental group showed the following performance:piloerection,arched,cured up and trembling;but the rats in control group did not show above performance.The fibrinogen of rats in experimental group was obviously lower than that of rats in control group(P0.01);While the prothrombin time,thrombin time,thromboplastin time and international normalized ratio were obviously higher(P0.01,P0.05).Conclusions:PHA can induce agglutination reaction in vivo and in vitro;it also can activate coagulation system.Clinical application should pay attention to its' effects on coagulation system.
【CateGory Index】: R392-33
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