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《Journal of Chengde Medical College》 2017-01
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EFFECTS OF CHRONIC CEREBRAL ISCHEMIA ON CALCIUM CHANNEL CAV1.3 EXPRESSION IN HIPPOCAMPUS OF RATS

GUO Sen;ZHU Jiang;Chengde Medical College;  
Objective: To investigate the changes of calcium channel Cav1.3 protein expression in hippocampus of chronic cerebral ischemia rats. Methods:36 male Wistar rats were randomly divided into sham-operation group, ischemia 7 days group and ischemia 14 days group. The chronic cerebral ischemia rats' model was established by blocking left vertebral artery and common carotid artery on both sides. Nissl's staining was used to observe the morphology of neurons in hippocampus CA1 region,Western Blot to detect calcium channel Cav1.3 protein expression in hippocampus. Results:Compared with 7 days group, the pathological changes of neurons in hippocampus CA1 region of rats in 14 days group markedly aggravated. With prolongation of ischemic time, the calcium channel Cav1.3 protein expression obviously decreased. Conclusions:Chronic cerebral ischemia may affect the normal function of hippocampal neurons by decreasing the expression of calcium channel Cav1.3 protein in hippocampus.
【CateGory Index】: R743
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 LIU Hui,ZHANG Jun-jian,ZHANG Lei.Department of Neurology,Zhongnan Hospital of Wuhan University, Wuhan,430071,China;The ethology representation of the modified three-vessel-occlusion rat model of chronic cerebral hypoperfusion[J];中华行为医学与脑科学杂志;2009-11
2 LI Xiao Ming, LI Jian Guo, HU Ping, YANG Jian Ming, WANG Ying, LI Xiao Wen, GAO Tian Ming ** (Department of Anatomy, Department of Physiology, The First Military Medical University, Guangzhou 510515, China);Changes in Single L-Type Calcium Channel Currents in CA1 Pyramidal Neurons of Rat Hippocampus After Transient Forebrain Ischemia[J];生物化学与生物物理进展;2003-05
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 GUO Sen;ZHU Jiang;Chengde Medical College;;EFFECTS OF CHRONIC CEREBRAL ISCHEMIA ON CALCIUM CHANNEL CAV1.3 EXPRESSION IN HIPPOCAMPUS OF RATS[J];承德医学院学报;2017-01
2 GUO Sen;ZHU Jiang;WANG Yongwei;Department of Human Anatomy,Affiliated Hospital of Chengde Medical College;;Effects of n-butylphthalide on expression of calcium channel Cav1. 3 in ischemic cerebral cortex in rats[J];中风与神经疾病杂志;2016-01
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 HU Ping 1) , LI Xiao Ming 1) , LI Jian Guo 1) , WANG Ying 1) , HUANG Qiao Bing 2) , GAO Tian Ming 1)** ( 1) Department of Physiology, The First Military Medical University, Guangzhou 510515, China; 2) Depart;Brief Ischemia Decreases Large Conductance Ca~( 2+)-activated K~+ Channel Activity in CA1 Pyramidal Neurons From Rat Hippocampus[J];生物化学与生物物理进展;2002-05
2 WAN Hong-ping,ZHANG Jun-jian,WANG Chang-yin.Department of Neurology,Zhongnan Hospital,Wuhan University,Wuhan 430071,China;Cognitive function and cerebral blood flow in chronic cerebral circulation insufficiency[J];中华行为医学与脑科学杂志;2007-01
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