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《Journal of Chengde Medical College》 2017-01
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RELATIONSHIPS BETWEEN SERUM MMP-9 LEVEL AND COGNITIVE DYSFUNCTION OF PATIENTS WITH ACUTE CEREBRAL INFARCTION

YANG Xue;DOU Zhi-jie;WANG Bo;Chengde Medical College;  
Objective: To observe the relationships between serum matrix metalloproteinase-9(MMP-9) level and cognitive dysfunction after cerebral infarction of patients with acute cerebral infarction. Methods: Initial cerebral infarction patients were divided into cognitive dysfunction group(≤26) and non cognitive dysfunction group(26) according to Mo CA score. Healthy checkup at the same term were taken as healthy control group. ELISA was used to detect the serum MMP-9 level of 124 subjects. Results: The serum MMP-9 level of patients in cognitive dysfunction group was obviously higher than non cognitive dysfunction group and healthy control group(P0.05). Logistic regression showed that MMP-9 and age were independent risk factors for cognitive dysfunction after cerebral infarction. Conclusions: Increasing of serum MMP-9 level in patients with acute cerebral infarction maybe related to cognitive dysfunction after cerebral infarction.
【CateGory Index】: R749.13
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