EXPRESSION AND CLINICAL SIGNIFICANCE OF SGK3 IN COLON CANCER
SONG Tai-ning;JIA Xi-hua;WANG Jing-miao;Chengde Medical College;
Objective:To investigate the expression and clinical significance of serum/glucocorticoid regulated kinase 3(SGK3) in colon cancer. Methods: SP immunohistochemical method was used to detect the expression of SGK3 in 70 cases of colon cancer tissues and 30 cases of adjacent normal tissues; And the relationships between SGK3 expression and pathological features of colon cancer were also analyzed. Results: The SGK3 expression in colon cancer was 74.3%(52/70), which was significantly higher than that in adjacent normal tissue(16.7%, 5/30)(P0.05). In colon cancer, the SGK3 expression was related to TNM stage, depth of invasion and lymph node metastasis(P 0.05); but was irrelevant to age, gender, tumor size and histopathological differentiation(P 0.05). Conclusions: High expression of SGK3 may participate the development of colon cancer, and maybe related with the poor prognosis of colon cancer.
【CateGory Index】： R735.35