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《Journal of Chongqing Institute of Technology Management》 2003-01
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Study on the Structural Characteristics of the Peptide Sequence and Its Relation with Immune Cell

LIN Zhihua,QUAN Xuejun,ZHOU Yuegang(College of Bioengineering, Chongqing Institute of Technology, Chongqing 400050,China)  
The goal of this study is to develop an automated computerized method for the identification of Thcell epitope. Based on the distance between each amino acid side chain and on the electric property of each amino acid side chain, a new set of descriptors called sequence property vector (ζ,in short) is developed from the primary structures of peptides to describe the peptide structure and each amino acid side chain is seen as a pseudo atom. Then a quantitative model is proposed for 28 immunogenic peptides including 14 Ad and nonAd restricted peptide sequence chosen from the reference, which are defined as actives and inactives respectively. In order to test the accuracy of the prediction system, random sampling validation and cross validation are performed. The results show that the prediction system exhibits both good stability and excellent prediction ability. This method also may be applied in the study to predict the MHC class I and class II epitope of human, and it should be useful in immune recognition studies of protein antigens and the design and study of subunit vaccine.
【CateGory Index】: Q516
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