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《Journal of Yangtze University(Natural Science Edition)》 2011-03
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Application Comparison of Two Adjuvants in Preparation of Recombinant Subunit Vaccine of Infectious Bursal Disease

CAI Lian-shen, RONG Jun College of Life Science,Yangtze University,Jingzhou,Hubei 434025, China  
In order to improve the effect and safety of the vaccine adjuvant in production of the recombinant subunit vaccine of infectious bursal disease (IBD),four types different of IBD vaccines were prepared as follow: two types of shortening adjuvant which AGP titer were separately 1∶32 and 1∶16; two types of 603 new nanometer adjuvant which AGP titer were separately 1∶32 and 1∶16.Two types of control groups were prepared. For testing the effect and safety of the vaccines, those vaccines were injected into SPF chickens with two different doses. The results of effect test showed that the chicken antibody of shortening adjuvant groups was higher than the antibody of the 603 new nanometer adjuvant groups when the injection dose of the antigen was the same. The level of the chickens,antibody was on the rise after the 14th to 21st days of injections of the shortening adjuvant IBD vaccine, but the chickens were injected by 603 new nanometer adjuvant IBD vaccine, the level of antibody was not on the rise after14th days. The results of the safety test showed that the safety of the 603 new nanometer adjuvant IBD vaccine was much better than the shortening adjuvant IBD vaccine. The results can provide reference for improving the manufacturing process of the recombinant subunit vaccines of IBD.
【Fund】: “十一五”国家科技支撑计划项目(2006BAD06A08)
【CateGory Index】: S852.53
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