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《Chinese Journal of Neuromedicine》 2007-11
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Correlation between learning and memory impairment and the changes of intracellular free Ca~(2+) concentration in hippocampal neurons after temporal lobe epilepsy in rats

QIAN Ruo-bing FU Xian-ming NIU Chao-shi WANG Ye-han WEI Jian-jun LU Ming WANG Lin.Department of Neurosurgery,Anhui Provincial Hospital Affiliated to Anhui Medical University,Hefei 230001,China  
Objective To explore the correlation between learning and memory impairment and the changes of intracellular free Ca~(2+)concentration([Ca~(2+)]i)in hippocampal neurons at different periods after seizures of temporal lobe epilepsy(TLE)in rats.Methods The kainic acid-induced TLE models in Sprague-Dawley(SD)rats were established with stereotactic techniques.The extent of learning and memory impairment was evaluated by the Morris water maze test;changes of[Ca~(2+)]i in hippocampal neurons at different periods were measured with Ca~(2+)-sensitive fluorescent probe Fluo-3/AM and laser scanning confocal microscope(LSCM).Results All rats developed learning and memory impairment to the certain extent,after seizures of TLE induced by kainic acid injection into the right hippocampus, which deteriorated with seizures in a time-dependent manner and rose to the climax 2 months later after seizures.The fluorescence intensity of[Ca~(2+)]i in right hippocampal neurons increased evidently after seizures of TLE:it rose to its climax at 6 h,maintaining a comparatively high level within the 2 months after seizures[its comparison with the normal control and normal saline ingection group was significant (P0.05)],but began to decrease 3 months later after seizures,tending to be lower than that of the normal control group;the fluorescence intensity of[Ca~(2+)]i in contralateral hippocampal neurons was higher than that of the normal control and normal saline injection groups,but still lower than that of the right hippocampal neurons.Conclusion Learning and memory impairment of the rats after seizures of TLE become aggravated in a time-dependent manner with seizures and culminates at 2 month,which has some time correlation with changes in[Ca~(2+)]i of h ippocampal neurons.
【Fund】: 安徽省高等学校自然科学研究项目(2005KJ345zc,2005KJ359zc)
【CateGory Index】: R742.1
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【Citations】
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