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《Chinese Journal of Neuromedicine》 2007-11
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Effect of mild hypothermia on the serum level of IL-6 and expression of ICAM-1 after MCAO in rats

FU Sheng-qi XING Hong-xia MAO Xing-ai.Department of Neurology,the First Affiliated Hospital of Xinxiang Medical College,Weihui 453100,China  
Objective To investigate the effect of mild hypothermia on the expression of intracellular adhesion molecule-1(ICAM-1)in the ischemic area and the serum level of interleukin-6 (IL-6)after middle cerebral artery occlusion(MCAO)in rats,and to discuss the neuroprotective mechanism of mild hypothermia in treating ischemic brain injury.Methods Thirty female Sprague-Dawley rats weighing 250-300 g were randomly assigned to the experiment group(n=15)and the control group(n=15).Focal cerebral ischemia models were estallished in rats by occlusion of the unilateral middle cerebral artery with intraluminal thread.After the successful establishment of MCAO models in rats,the experiment and control groups were located on the ice blanket machine and the normal temperature operating table,respectively.The rectal temperature of the experiment group was controlled at(33±1)℃after MCAO,and that of the control group was(37±0.5)℃after MCAO.Twelve hours later, blood samples were drawn from the left ventricle and removed the brains by decollation. Immunohistocbemical analysis was used to test the number of ICAM-1 positive vessels in the ischemic area and immunoradiometric assay(IRMA)was used to test the serum level of IL-6.Results Immunohistochemical analysis showed that the expression oflCAM-1 in the ischemic area of brain in the experiment group was lower than that in the control group.The serum level of IL-6 measured by IRMA in the experiment group was lower than that in the control group.Conclusion Mild hypothermia can reduce the serum level of IL-6 and the expression oflCAM-1 in the ischemic area after cerebral ischemia. It can be predicted that reducing the expressions of IL-6 and ICAM-1 is one of the neuroprotective mechanisms of mild hypothermia in treating ischemic brain injury.
【CateGory Index】: R743.31
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