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《Chinese Journal of Neuromedicine》 2007-11
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Effects of different erythropoietin treatment courses on apoptosis of neuronal cells in rats following ischemia-reperfusion injury

DING Zheng-bin QUAN Wei CAO Zhi-kai Lü Jian-ping YANG Bin-yuan ZHANG Hao CHEN Fan-fan.Department of Neurosurgery,First People's Hospital of Guangzhou,Guangzhou Medical College,Guangzhou 510180,China  
Objective To explore the effects of different erythropoietin(EPO)treatment courses on apoptosis of neuronal cells in rats after ischemia-reperfusion injury(I-RI).Methods A total of 36 male Sprague-Dawley(SD)rats were randomized into two groups:EPO treatment group and normal saline group.Each group was divided into three subgroups respectively with the short-,middle- and long-term therapeutic course and rat models of focal cerebral I-RI were established in both groups. EPO treatment groups received intraperitoneal injection of EPO at 3000 U/kg body weight respectively at a certain time point during the short-,middle-and long-term course of treatment,while the normal saline group received the same dose of normal saline,The neurological function of rats was scored at 24 h after administration;paraffin sections were produced with the removed rat brain decapitated at a certain time point of treatment;the expression of caspase-3 and apoptosis of neuronal cells were detected with immunohistochemical techniques and flow cytometry,respectively.Results The neurological function of EPO subgroups was relatively improved,compared with that of the normal saline group,but the number of apoptotic neuronal cells and expression of caspase-3 were all decreased,especially significantly in the long-term treatment group,which differed from that in the short-and middle term treatment groups significantly(P0.05).Conclusion EPO of different courses of treatment exerts different impacts upon apoptosis of neuronal cells after I-RI and long-term EPO treatment course may be the optimal choice,
【Fund】: 广州市医药卫生科技项目(2006-YB-029)
【CateGory Index】: R741
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