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《Chinese Journal of Neuromedicine》 2007-11
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Study on the expression of c-Jun in intracraniai aneurysms and its regulatory effect on the expression of MMP-9

GUO Yu-da LI Zhao-jie ZOU Zhao-xia YOU Chao.Department of Neurosurgery,Guangdong Provincial People's Hospital,Guangzhou 510080,China  
Objective To investigate the expression ofc-Jun in intracranial aneurysms and its significance of regulating the expression of matrix metailoproteinase-9(MMP-9).Methods The immune activity of c-Jun and expression level of MMP-9 mRNA in tissue samples of the brain blood vessel wall from 15 intracranial aneurysms and normal brain vessels of six patients without cerebral vascular diseases were determined with the immunohistochemical streptavidin-peroxidase(SP)method and real-time quantitative reverse transcriptase-polymerase chain reaction(RT-PCR),respectively. Results The immune activity ofc-Jun in tissue samples ofintracranial aneurysm wall was significantly upregulated compared with that of normal brain blood vessel wall(1.92±0.51 vs 0.17±0.41);the difference between them was significant(P0.01).The expression level of MMP-9 mRNA in tissue samples ofintracranial aneurysm wall was 10.06-fold of that in the normal brain vessels(P0.01).The immune activity of c-Jun and expression level of MMP-9 mRNA in tissue samples of intracranial aneurysm wall were positively correlated with each other(r=0.818,P0.001).Conclusion Augmented immunoreactivity of transcription factor c-Jun is one of the critical factors in inducing the expression of MMP-9 to participate in the pathogenesis of intracranial aneurysms.
【CateGory Index】: R651
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1 YAN Yun-feng;ZHAO Quan-ming;ZHANG Ling;ZHANG Ming-duo;LI Xin-he;Beijing Institute of Heart;Lung and Blood Vessel Diseases-Beijing Anzhen Hospital,Capital University of Medical Sciences;;Predictive value of positron emission tomography and computed tomography to development of aortic aneurysm: a Meta-analysis[J];中国循证心血管医学杂志;2015-06
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