Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Neuromedicine》 2007-11
Add to Favorite Get Latest Update

Study on the expression of c-Jun in intracraniai aneurysms and its regulatory effect on the expression of MMP-9

GUO Yu-da LI Zhao-jie ZOU Zhao-xia YOU Chao.Department of Neurosurgery,Guangdong Provincial People's Hospital,Guangzhou 510080,China  
Objective To investigate the expression ofc-Jun in intracranial aneurysms and its significance of regulating the expression of matrix metailoproteinase-9(MMP-9).Methods The immune activity of c-Jun and expression level of MMP-9 mRNA in tissue samples of the brain blood vessel wall from 15 intracranial aneurysms and normal brain vessels of six patients without cerebral vascular diseases were determined with the immunohistochemical streptavidin-peroxidase(SP)method and real-time quantitative reverse transcriptase-polymerase chain reaction(RT-PCR),respectively. Results The immune activity ofc-Jun in tissue samples ofintracranial aneurysm wall was significantly upregulated compared with that of normal brain blood vessel wall(1.92±0.51 vs 0.17±0.41);the difference between them was significant(P0.01).The expression level of MMP-9 mRNA in tissue samples ofintracranial aneurysm wall was 10.06-fold of that in the normal brain vessels(P0.01).The immune activity of c-Jun and expression level of MMP-9 mRNA in tissue samples of intracranial aneurysm wall were positively correlated with each other(r=0.818,P0.001).Conclusion Augmented immunoreactivity of transcription factor c-Jun is one of the critical factors in inducing the expression of MMP-9 to participate in the pathogenesis of intracranial aneurysms.
【CateGory Index】: R651
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 3 Hits
1 LIU Bing, PU Pei-yu, ZHANG Jian-ning, GAO Yong-zhong. Department of Neurosurgery, Tian Jin Medical University General Hospital, Tian Jin 300052, China;Effects of PDGF-B and IL-1α on the expression of MMP-1 mRNA in the cultured aorta smooth muscle cells of rats[J];中华神经医学杂志;2005-09
2 LI Da yong, ZHANG Qiang, CHE Yan, QI Ming, YANG Yong, LUO Tao, DUAN Zhi quan Department of Vascular Surgery, The First Affiliated Hospital, China Medical University, Shenyang 110001, China Corresponding author: ZHANG Qiang;Effects of macrophage infiltration and related gene expression on the pathogenesis of early abdominal aortic aneurysm[J];中华医学杂志;2003-18
3 HAN Lijiang, ZHAO Jizong, WANG Shuo, et al. Dept. Neurosurgery, Beijing Tiantan Hospital, Beijing 100050;In situ localization of mRNA for 72 and 92 KDa type Ⅳ collagenase in aneurysms and the same patients' cortical arteriolae[J];中华神经外科杂志;1999-03
Chinese Journal Full-text Database 10 Hits
1 YAN Yun-feng;ZHAO Quan-ming;ZHANG Ling;ZHANG Ming-duo;LI Xin-he;Beijing Institute of Heart;Lung and Blood Vessel Diseases-Beijing Anzhen Hospital,Capital University of Medical Sciences;;Predictive value of positron emission tomography and computed tomography to development of aortic aneurysm: a Meta-analysis[J];中国循证心血管医学杂志;2015-06
2 SERICK Du-ysenbi,ZHOU Kai,ARDAH Hu-napia, LIU Chen,GENG ? DANGMUREN ? Jiafu.Department of Neurosurgery,First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China;Expression of angiogenic growth factors and structural proteins in Kazakh patients with ruptured and unruptured cerebral aneurysms in Xinjiang[J];中华神经外科杂志;2011-11
3 GUO Yu-da LI Zhao-jie ZOU Zhao-xia YOU Chao.Department of Neurosurgery,Guangdong Provincial People's Hospital,Guangzhou 510080,China;Study on the expression of c-Jun in intracraniai aneurysms and its regulatory effect on the expression of MMP-9[J];中华神经医学杂志;2007-11
4 GUO Yuda1, LIN Xiaofeng1, YOU Chao21. Department of Neurosurgery, Guangdong Provincial Hospital, Guangzhou 510080, China; 2. Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, China;MMP-9 and ultrastructural study of intracranial aneurysms[J];中国微侵袭神经外科杂志;2007-05
5 SUN Xiao-feng,QIAO Gui-rang, HU Yu-hua ,et al. Department of Neurosurgery ,2nd Teaching Hospital of Hebei Medical University, Shi-jiazhuang 050000,China;Expression of matrix metalloproteinases 2 and 9 and their inhibitor-tissue inhibitor of metalloproteinase-1 in hypertension-induced cerebral aneurysm in rats[J];中华实验外科杂志;2006-12
6 SUN Xiao-feng QIAO Gui-rong LAN Hai-tao Department of Neurosurgery,2nd Teaching Hospital of Hebei Medical University,Shijiazhuang City 050000,China;The relationship between the expression of the NF-kB and MMPs in hypertension induced cerebral aneurysm in rats[J];中华神经外科杂志;2006-10
7 CHE Yan~1,LI Da-yong~2,HU Xin-hua~2,ZHANG Qiang~2,GUO Bing-xiong~1,XU Lin~1(1.Department of Cardiovascular Surgery,Shenzhou Hospital Affiliated to Shenyang Medical College,Shenyang 110002,China;2.Department of Vascular Surgery,The First Hospital Affiliated to China Medical University);The Dynamic Expression of Intercellular Adhesive Molecule-1 on Early Abdominal Aortic Aneurysm in Rats[J];沈阳医学院学报;2006-01
8 CHE Yan~*,ZHANG Qiang,LI Da-yong,et al.~*Department of Cardiovascular Surgery,The Second Affiliated Hospital,Shenyang Medical College,Shenyang 110002,China;The dynamic expression of heme oxygenase-1 in early abdominal aortic aneurysm in rats[J];中华实验外科杂志;2005-06
9 LI Da-yong *, ZHANG Qiang, CHE Yan, YANG Jing, SONG Cun-xian, LU Yan-wei. *Department of Vascular Surgery, First Affiliated Hospital, China Medical University, Shenyang 110001,China;Microparticle-mediated antisense monocyte chemotactic protein-1 transfection inhibits the development of abdominal aortic aneurysms in rats[J];中华老年医学杂志;2004-05
10 LI Da-yong,YANG Yong,ZHANG Qiang,et al.Department of Vascular Surgery,First Clinical College,China Medical University,Shenyang 110001,China;Effects of expression of hypoxia inducible factor-1 alpha on the formation of abdominal aortic aneurysms[J];中华实验外科杂志;2004-04
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 LIU Bing, GAO Yong-zhong, PU Pei-yu. Department of Neurosurgery, General Hospital, Tianjin Medical University, Tianjn 300052, China;Experimental Model of Saccular Aneurysms in Rats[J];中国临床神经外科杂志;2004-06
2 Zhang Jian; Wang Xinwen; Duan Zhiquan; et al.( Department of General Surgery, The First Clinical College, China Medical University, Shenyang 110001);Expression of matrix metalloproteinase in human abdominal aortic aneurysm tissue[J];中华实验外科杂志;1999-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved