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《Chinese Journal of Neuromedicine》 2007-11
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Study on the impact of probucol on expressed genes related with restenosis after carotid endarterectomy

LIANG Chun-yang ZHAO Chun-ping DAI Yi-wu HE Jiang-hong LI Yun-jun.Department of Neurosurgery,General Hospital of Beijing Military Area Command of Chinese PLA,Beijing 100700,China  
Objective To observe the effects of the antioxidant probucol on early restenosis after carotid endarterectomy(CEA)and its mechanism.Methods Carotid atberosclerotic models of New Zealand rabbits were established by air-drying plus high-cholesterol diet feeding,and CEA was performed on these animal models.Fourteen days before CEA,rabbits of the experimental group were garaged with probucol through the gastric tube and a control group was established for comparison. Pathological and immunohistochemical techniques were applied to detect the effects of probucol on apoptosis and expressions of intercellular adhesion molecule-1(ICAM-1)and matrix metalloproteinase-2 (MMP-2)during early restenosis following CEA.Results The antioxidant probucol could effectively reduce the neointima thickness after CEA and proliferation and migration of vascular smooth muscle cells (VSMCs),increase postoperative area of vascular residual cavity,upregulate the expression of Bcl-2, suppress apoptosis in the neointima and inhibit the expression of ICAM-1 and MMP-2 after CEA. Conclusion The antioxidant probucol can inhibit restenosis after CEA possibly through decreasing expressions of ICAM-1 and MMP-2 and the apoptosis of the neointima.
【CateGory Index】: R651.12
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【References】
Chinese Journal Full-text Database 1 Hits
1 Liang Chun-yang,Dai Yi-wu,Shen Chun-sen,Wei Qun,Li Yun-jun,Luo Yong-chun Department of Neurological Surgery,General Hospital of Beijing Military Area Command of Chinese PLA,Beijing 100700,China;Role of matrix metalloproteinase-9 dynamic expression in the development of early vascular restenosis after carotid endarterectomy[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2009-28
【Citations】
Chinese Journal Full-text Database 2 Hits
1 LIANG Chun-yang,ZHOU Ding-biao,YU Xin-guang,ZHANG Wen-bin,WANG Shi-bo(Department of neurological surgery,PLA General Hospital,Beijing 100853,China);Experimental study of healing process following sutureless adhesive anastomosis of carotid endarterectomy[J];Academic Journal of PLA Postgraduate Medical School;2006-05
2 LIU Ge-Xiu, OU Da-Ming, LI Li-Xin, CHEN Lin-Xi, HUANG Hong-Lin, LIAO Duan-Fang, TANG Chao-Shu' (institute of Pharmacy & Pharmacology, Nanhua University, Hengyang 421001, Hunan; Department of Cardiovascular Research , the First Hospital, Peking University, Beijing 100034, China);Probucol inhibits oxidized-low density lipoprotein-induced adhesion of monocytes to endothelial cells in vitro[J];中国药理学报(英文版);2002-06
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 Department of Neurology,the Affiliated Kailuan Hospital,Northern China Coal Medical College(Tangshan 063000)Hou Xiaoqiang Xue Fei Yuan Jianxin et al;The anti-oxidation and anti-inflammation effects of probucol in the patients with carotid atherosclerosis disease[J];Shaanxi Medical Journal;2008-12
2 HOU Xiao-qiang,XUE Fei,YUAN Jian-xin,et al.(Department of Neurology,The Affiliated Kailuan Hospital,Northern China Coal Medical College,Tangshan 063000,China);The anti-oxidation and anti-inflammation function of probucol in the patients with carotid atherosclerosis disease[J];Journal of Apoplexy and Nervous Diseases;2008-04
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 XU Yong-ge,ZHOU Ding-biao,ZHENG Ji-yi,et al.Department of Neurosu rgery,General Hospital of PLA,Beijing100853,Chi na;Establishment of an animal model of carotid atherosclerotic stenosis[J];Chinese Journal of Neurosurgery;2003-04
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