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《Materials Review》 2017-13
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Effect of Surface Microroughening of Titanium Alloy on Osteoblast Adhesion and Proliferation Behavior

HUANG Run;WANG Qingping;ZHANG Lan;CHEN Xiangyang;HU Dong;School of Materials Science and Engineering,Anhui University of Science and Technology;State Key Laboratory for Mechanical Behavior of Materials,Xi'an Jiaotong University;School of Mechanical Engineering,Anhui University of Science and Technology;Medical Inspection Center,Anhui University of Science and Technology;  
Ti-25Nb-3Mo-3Zr-2Sn(TLM)titanium alloy was treated via surface mechanical attrition treatment(SMAT)for 15 min in this paper,after which the treated and untreated titanium alloy samples were respectively cultured with osteoblast cells for 1h and 24 h.XRD,OM,TEM,SEM,EDX and CLSM were adopted to analyze the structure of the samples,and the obtained results revealed that SMAT process did not alter the phase composition,grain size and chemical composition of TLM alloy.Both the treated and untreated titanium alloys were composed of the same solelyβphase,in the same grain size of about 10—20μm and without newly-brought impurity elements.However,this treatment would alter the surface roughness of TLM alloy.The untreated sample possessed a smooth surface with a roughness value Raof about(0.2±0.03)μm,whereas the treated surface owed an uneven surface with a roughness value Ra of about(2.6±0.4)μm.The subsequent cellular experiment showed that the seeded osteoblasts on SMAT-treated surface spread much wider and proliferated more rapidly compared with the untreated surface.Our study suggests that SMAT could improve the living condition of osteoblast on TLM alloy surface,thus providing apromising means for the design of more potential biomedical titanium implants used on clinic.
【Fund】: 国家自然科学基金(81501598);; 西安交通大学金属材料强度国家重点实验室开放研究项目(20161805);; 安徽理工大学引进人才科研启动基金(ZY533)
【CateGory Index】: R318.08
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