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《Materials Review》 2018-S1
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Preparation and Application of Chitosan Hydrogel in Drug Controlled Release System

CHEN Zhijie;CHEN Yanfang;ZHENG Jun;XU Xiaoyan;School of Materials Science and Engineering,Tongji University;Yueyang Hospital of Integrated Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine;  
Hydrogels have a wide application in drug controlled release,tissue engineering and other fields due to their excellent properties.Chitosan is a natural alkaline polysaccharide with positive charge and chitosan hydrogels have extensive applications in biological field due to their good biocompatibility,biodegradability,antibacterial and low toxicity.In this paper,the preparation methods of chitosan hydrogels including physical crosslinking methods and chemical crosslinking methods have been summarized firstly.In the part of physical crosslinking methods,the use of ionic compounds and polyelectrolyte complexes is mainly introduced.We also have a brief introduce about the use of hydrophobic interaction between chitosan chains.And in the part of chemical crosslinking methods,the chemical methods for the preparation of chitosan hydrogels have been introduced,including the use of crosslinking agents,light radiation and enzyme.Then,the research progress of chitosan hydrogels in drug controlled release have been summarized,including temperature,pH value and electric field response controlled release system.Finally,the potential applications of chitosan hydrogels in the future are proposed.
【Fund】: 国家留学基金委青年骨干教师出国研修项目
【CateGory Index】: TQ427.26;TQ460.1
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