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《Materials Review》 2018-S1
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Research Progress of Zn-based Biodegradable Metallic Materials

FENG Xiangyi;ZHOU Chao;ZHANG Haijun;National United Engineering Laboratory for Biomedical Material Modification;Institute of Vacular Intervention,Medical College of Tongji University;  
With the change in medical perception and the progress of material science,the choice of medical metal implant materials has been through a variation from corrosion-resistant materials to biodegradable materials.To mitigate the long-term side effects associated with corrosion-resistant stents(i.e.chronic inflammation and late stage thrombosis),a new generation of so-called"bioabsorbable"stents is currently being developed.The bioabsorbable coronary stents will corrode and be absorbed by the artery after completing their task as vascular scaffolding.The current biodegradable metallic materials mainly include magnesium-based alloy,iron-based alloy and zinc-based alloy.Unfortunately,iron produces a voluminous,retained oxide product in the arterial wall,whereas magnesium and its alloys corrode too rapidly.As summarized in this contribution,this new zinc-based class of materials demonstrates the potential for an absorbable metallic stent with the mechanical and biodegradation characteristics required for optimal stent performance.In this paper,the current research status of the zinc-based alloy had been reviewed.
【Fund】: 国家重点研发计划(2016YFC1102500)
【CateGory Index】: R318.08
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