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《Materials Review》 2018-S1
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Research Progress on Degradation Behavior of the Biodegradable Materials for Vascular Stents

CUI Xiaoshan;ZHOU Chao;ZHANG Haijun;National United Engineering Laboratory for Biomedical Material Modification Branden Industrial Park;Institute of Interventional & Vascular Surgery,Tongji University;  
The bioresorbable materials of stents include polymer,magnesium-based alloy,iron-based alloy and zinc-based alloy.Degradation properties of these materials directly affect their support capability,local response and long-term vascular repair prognosis after implantation.The polymer has large adjustable degradation time range,good bio-compatibility,but lacks the mechanical property.The problem of magnesium alloy is the fast degradation rate,the release of local hydrogen and relatively large pH variation in micro-environment.On the other side,ferroalloys degrade too slow compared to magnesium alloy.Among all,the performance of zinc alloys seems more appropriate in terms of degradation behavior and corrosion rate.It has become a new promising implantable and biodegradable metallic material for vascular applications in recent years.In addition to its own nature,the degradation behaviors of the bioresorbable material within blood vessel are also influenced by in-vivo factors such as ion concentration,enzyme,pH value and temperature in local environment.This review introduces the corrosion degradation behavior of different materials in simulated body fluids and animal body,providing references for the research and product development of degradable materials in blood vessels.
【Fund】: 国家重点研发计划(2016YFC1102500)
【CateGory Index】: R318.08
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