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The Changes of TNF_α,IL-6 and IL-8 in Lung and Plasma in Rats With Lung Ischemia-reperfusion Injury and Their Singificances

Xiang Mingzheng,et al. Department of Thoracic Surgery, (The Xinqiao Hospital of Third Militarty medical University, Chongqing 400037)  
To investigate the role of inflammatory cytokines in the pathogenesis of lung ischemia-reperfusion injury , the rat ischemia model with occlusion of left hilus for 45-minute was set up and the changes of levels of TNF_α,IL-6 and IL-8 in lung tissues and plasma were dynamically observed during lung ischenia-reperfusion. The results showed that the releases of TNF_α,IL-6 and IL-8 in lung tissues were successively increased in the early stage of lung damage and the alterations of above-mentioned cytokines in plasma lagged those in lung tissues. It is concluded that inflammatory cytokines could participated in the onset and development of lung ischemia-reperfusion injury.
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