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《Chongqing Medical Journal》 2003-12
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YMDD mutation of HBV after treatment with Lamivudine

CHEN Wei,DENG Shao li,CHEN Ying chun (Dapartment of Clinical Laboratories,Daping Hospital,the Third Military Medical University,Chongqing 400042,China)  
Objective To investigate YMDD mutation of HBV after treatment with Lamivudine.Methods Eighty seven patients with chronic hepatitis B were divided into two groups.One group (with 51 patients) was treated with Lamivudine and liver protecting drugs,the other (with 36 patients) was treated only with liver protecting drugs.YMDD mutation was analyzed after 1 year.Serum HBV DNA and ALT levels were also detected.Results Eight cases of YMDD mutation were found in the group treated with Lamivudine,and no YMDD mutation in the other group.Conclusion Lamivudine can lead to YMDD mutation in HBV polymerase gene,resulting in resistant strains.
【CateGory Index】: R512.62
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【References】
Chinese Journal Full-text Database 8 Hits
1 YANG Ming,CHEN You-jiang,WEN Ming-bo,et al.(1.Department of Medical Affairs;2.Department of Hepatobiliary Dsease,181 Hospital of PLA,Guilin 541000,China;3.Institute of Hepatobiliary Surgery of PLA,First Affiliated Hospital,Third Military Medical University,Chongqing 400038,China);Prophylaxis of reinfection of HBV with low-dose HBIg and lamivudine after liver transplantation[J];Chongqing Medicine;2007-11
2 ZHOU Li-xin,CHEN Lan,WEI Zhong-hua,et al.(Department of Clinical Laboratory,Dazhou Central Hospital,Dazhou,Sichuan 635000,China);Evaluation on laboratory indexes in treating chronic hepatitis B[J];Chongqing Medicine;2009-01
3 CHEN Qiang,QIU Bang-dong.The Second People`s Hospital of Yibin City,Yibin 644000,Sichuan.P.R.CHINA;Anti-virus therapy of entecavir in the treatment of chronic hepatitis B at the initial stage[J];Hainan Medical Journal;2009-S4
4 WANG Yu-min ,TAO Zhi-hua ,ZHU Yan-ying,et al (Department of Laboratory Medicine,the First Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,China);Detecting of the hepatic-fibrosis index and serous markers from HBV DNA YMDD mutation of the patients with chronic hepatitis (CH)[J];Zhejiang Journal of Laboratory Medicine;2006-03
5 WANG Yu-min,TAO Zhi-hua,ZHU Yan-ying,et al.(Department of Laboratory Medicine,the First Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,China);Detecting of the hepatic fibrotic indexes and serous markers from patients with chronic hepatitis B(CHB) and variation of HBV DNA YMDD[J];Chinese Journal of Clinical Hepatology;2007-03
6 CHEN Qiang,QIU Bang-dong.The Second People′s Hospital ofYibin,Yibin,Sichuan644000,China;Clinical observation about anti-virus therapy of entecavir in treating chronic hepatitis B at the initial stage[J];Sichuan Medical Journal;2009-12
7 TIAN Huaiyu The Zhoukou City Specialist Hospital of Henan Province,Zhoukou 466000,China;Lamivudine Combined with Compound Biejiaruan Tablets in Treatment of Hepatitis B Patients with Liver Fibrosis[J];China Modern Doctor;2009-30
8 ZHANG Bing-bing.The third people's hospital of Zhengzhou,Henan,Zhengzhou 450000;Comparing between Lamivudine and adefovir dipivoxil in treatment of hepatitis B patients with liver fibrosis[J];Chinese Journal of Modern Drug Application;2010-08
【Citations】
Chinese Journal Full-text Database 3 Hits
1 HUANG Yan ping, WANG Yu ming (Department of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Clinical observation of lamivudine therapy in 50 patients with chronic hepatitis B infection[J];Acta Academiae Medicine Militaris Tertiae;2002-11
2 YIN Shan - shan, YOU Hong, MA Hong, et aL. (Beijing Friendship Hospital, Capital University of Medical Sciences ,Beijing 100050);YMDD mutation after two - years lamivudine treatment in chronic hepatitis B patients[J];Chinese Journal of Clinical Hepatology;2002-01
3 YAN Jie,WANG Lei,XU Wan su,et al (Dept.of Infectious Diseases,Medical College of Shandong University);EFFECT OF HEPATITIS B VIRUS POLYMERASE YMDD VARIATION ON THE PATIENTS WITH CHRONIC HEPATITIS B TREATED WITH LAMIVUDINE[J];Acta Academiae Medicinae Shandong;2001-02
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Li Zhi-xia,Qin Xi,Qian Shi-yun.Department of Laboratory Medicine, Hainan Medical College, HaiKou HaiNan 570102.;Lamivudine resist the hepatitis B virus and treats YMDD mutation in Hainan areas[J];Chinese Journal of Laboratory Medicine Education;2005-03
2 WANG Yu-min ,TAO Zhi-hua ,ZHU Yan-ying,et al (Department of Laboratory Medicine,the First Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,China);Detecting of the hepatic-fibrosis index and serous markers from HBV DNA YMDD mutation of the patients with chronic hepatitis (CH)[J];Zhejiang Journal of Laboratory Medicine;2006-03
3 WANG Yu-min,TAO Zhi-hua,ZHU Yan-ying,et al.(Department of Laboratory Medicine,the First Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,China);Detecting of the hepatic fibrotic indexes and serous markers from patients with chronic hepatitis B(CHB) and variation of HBV DNA YMDD[J];Chinese Journal of Clinical Hepatology;2007-03
4 Xu Junyang The Second People's Hospital of Xuzhou Mineral Company;Therapeutic Observation of Lamivudine Combining with Yishusong on Hepatitis B[J];Qinghai Medical Journal;2004-12
5 WANG Lei, YAN Jie, LI Xiao-ying, et al (Dept. of Infectious Disease,School of Medicine,Shandong University);Predictive factors of variations in hepatitis B virus polymerase responsible for lamivudine resistance[J];Acta Academiae Medicinae Shandong;2002-01
6 WANG Lei, ZHANG Lu, YAN Jie(1.Institute of Infection Disease, School of Medicine, Shandong University,Jinan 250012,Shandong, China; 2.Beijing Ditan Hospital, Beijing 100000, China);Detection of M204V/M204I and L180M mutations in HBV DNA Polymerase associated with lamivudine resistance[J];Journal of Shandong Univenity(Health Scicnes);2005-02
7 YANG Zhi-zhao,LUO Yan-xiang,HE Jie-bing,et al (Zhongshan People’s Hospital,Zhongshan,Guangdong 528403,China);Use of Real-time PCR to Detect Mutations in the YMDD Region of the HBV Polymerase[J];Journal of Practical Medical Techniques;2004-16
8 YAN Jie,LI Xin,HE Zhongping.et al Ditan Hospital of Beijing , Bejing 100011 , China;Establishment and application of boiling method to extract HBV DNA from serum sample[J];Chinese Journal of Gastroenterology and Hepatology;2003-04
9 ZHANG Xiao-hong, LIN Guo-li, ZHU Jian-yun, CHEN Li, YANG Shao-ji, XIAO Jie-sheng. Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University of Medical Sciences, Guangzhou 510630, China;Clinical characteristics of and the related factors to the relapse of chronic hepatitis B after lamivudine withdrawal 2[J];Chinese Journal of Hepatology;2004-10
10 ZHAO Ai'ying Heze City Hospital,Heze 274031,China;Curative Effect of Combined Use of Martine and Lamivudine in Treatment of Chronic Hepatitis B[J];China Modern Doctor;2009-26
【Co-references】
Chinese Journal Full-text Database 9 Hits
1 YAN Jie,WANG Lei,XU Wan su,et al (Dept.of Infectious Diseases,Medical College of Shandong University);EFFECT OF HEPATITIS B VIRUS POLYMERASE YMDD VARIATION ON THE PATIENTS WITH CHRONIC HEPATITIS B TREATED WITH LAMIVUDINE[J];Acta Academiae Medicinae Shandong;2001-02
2 Zhu Xiaofeng, Chen Guihua , He Xiaoshun, et al. Transplantation Center, The First Affiliated Hospital of SUMS, Guangzhou 510080;Prevention and treatment of hepatitis B recurrence with Lamivudine after liver transplantation[J];Digestive Surgery;2002-01
3 Yang Ming, Wang Hui, Chen Youjiang, Wen Mingbo. Medical Administrative Division, 181th Hospital of PLA, Guiling 541002;Prevention and treatment for reinfection of HBV after liver transplantation[J];Digestive Surgery;2004-03
4 YU Zhen-dong~(1),WU Bo~(2),PENG Yan-zhong~(3),GUI Yao-ting ~(1)(1.Laboratory of Andriatries;2.Department of Dermatology;3.Department of Infectious Diseases,Shenzhen Hospital,Beijing University,Shenzhen 518036,China);Relationship between the Antiviral Effect and Changes in Helper T(Th) Cytokine Levels in the Treatment of Chronic Hepatitis B Using Lamivudine Combined with Alpha Interferon[J];Herald of Medicine;2005-12
5 GUShengWang, ZHANG Hong, ZHANG Lian, et al. (Dopsrtment of Infectious Disease, N8nfsng Hospital,Guangzhiou 510515);Relationship between serum fibrosis markers and fibrosis quantitative analysis of liver tissue[J];CHINESE JOURNAL OF HEPATOLOGY;1999-04
6 Chinese Society of Hepatology and Chinese Society of Infectious Diseases,Chinese Medical Association. 42 Dongsi Xidajie,Beijing 100710,China;The guideline of prevention and treatment for chronic hepatitis B[J];Chinese Journal of Hepatology;2005-12
7 YAO Guang bi, ALISON Tan Mulligan, HUANG Ying, et al. Shanghai Jing An Qu Central Hospital, Shanghai 200040;Evaluation of health related quality of life with treatment of lamivudine in chronic hepatitis B patients.[J];Chinese Hepatology;2003-04
8 LIU Chuanmiao, ZHANG Xinxin, LU Zhimeng. Ruijing Hospital, Shanghai Second Medical University,Shanghai 200025,China;Evolution of wild type and mutants of the YMDD motif of hepatitis B virus polymerase during lamivudine therapy[J];Chinese Hepatology;2004-02
9 LIU Li,CHENG Yue,KE Chang-zhen,et al. Department of Infectious Diseases,TaiHe hospital,Yunyang Medical college,Shiyan 442000,China;Lamivudine for hepatitis B patients with liver cirrhosis:A meta-analysis of randomized controlled trials in China[J];Chinese Hepatology;2007-05
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 YAO Guangbi; WANG Bao'en; CUI Zhenyu; et al.(The Jing'an Qu Central Hospital, Shanghai 200040);Long-term effect of lamivudine treatment in chronic hepatitis B virus infection[J];CHINESE JOURNAL OF HEPATOLOGY;1999-02
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