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《Chongqing Medical Journal》 2003-12
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Study the changes of S-100b in plasma and EEG in on-pump beating-heart intracardiac procedure with mild hypothermia

WANG Yong,XIAO Yin bing,CHEN Lin,et al (Department of Cardiovascular Surgery,Xinqiao Hospital,the Third Military Medical University,Chongqing 400037,China)  
Objective To observe the changes of S 100b in plasma and EEG in on pump beating heart intracardiac procedure with mild hypothermia.Methods Twenty patients with congenital heart disease underwent in on pump beating heart intracardiac procedures with mild hypothermia.We collected arterial blood samples at preoperation(time a),CPB twenty minutes(time b),one hour after CPB (time c),one day after operation(time d) and 7days after operation(time e).Levels of plasma protein S 100b were measured with ELISA.All patients were checked with EEG before,one day and seven days after operation.Results The levels of plasma protein S 100b increased significantly at time b,c and d( P 0.01).At the time e,the levels of S 100b returned to the nadir.The postoperative EEG abnormality rates were 90% in one day after operation and 65% in seven days after operation.Conclusion The on pump beating heart intracardiac procedures could make some cerebral injury.S 100b and EEG are important methods in finding and assessing the cerebral injury in on pump beating heart intrardiac procedure.
【CateGory Index】: R654.2
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