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《Chongqing Medical Journal》 2003-12
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Changes of endotoxin,TNF-α,IL-1β,IL-6 and IL-8 in serum of patients with severe trauma

LANG Zhong bing,WEN Liang (Department of Emergency,the First Affiliated Hospital,the Third Military Medical University,Chongqing 400038,China)  
Objective To investigate the changes of endotoxin,TNF α,IL 1β,IL 6 and IL 8 in the serum of patients with severe trauma and to explore the clinical significance.Methods Concentration of endotoxin in the serum of patients was measured by dynamic turbidity and TNF α,IL 1β,IL 6 and IL 8 were determined by radiommunoassay respectively in a week post trauma.Normal group was observed simultaneously.Results Serum endotoxin and cytokines in patients with severe trauma were shown to be significantly higher than healthy group.Endotoxin,TNF α and IL 1β were elevated at the early stage of trauma,peaked in 2 nd and 3 rd day respectively,significantly higher than normal in 7 th day.IL 6 and IL 8 were elevated more in 5 th to 7 th day than at the early stage,and had a rising trend.The ISS scores of patients were significantly correlated with the peaks of endotoxin and TNF α,the rate of increase of IL 6 in 5 th day after trauma.Endotoxin and cytokines in death group were higher than in survivor group in corresponding time point.Conclusions Severe trauma could induce marked endotoxemia and cytokine responses.To analyze trauma patient′s condition and prognosis could be beneficial from dynamic of endotoxin and cytokines.
【CateGory Index】: R641
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