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《Chongqing Medical Journal》 2003-12
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Expression of NOS and it′s relationship with nerve regeneration in rat brain after ~(60)Coγ irradiation

ZUO Yan fang,ZHANG Kun,GUO Guan jing (Department of Surgical Applied Anatomy and Operative Surgery,the Third Military Medical University,Chongqing 400038,China)  
Objective To study the expression rule of NOS after 60 Coγ irradiation induced central nerve damage and to analyse the possible effects of NOS to nerve regeneration after the damage.Methods Wistar rats were subjected to whole body irradiation with 8Gy 60 Coγ rays.The expression of NOS was detected by using NDP.Results The expression of NOS increased in cortex,caudate putamen,globus pallidus,thalamus and hypothalamus of rats one week after 8Gy 60 Coγ radiation.Four weeks after radiation the NOS expression reached its peak and began to decrease.But it still remained at a higher level than normal.Seven weeks after radiation it decreased to a low level.Conclusion Enhanced expression of NOS after 60 Coγ radiation in rats′ brain may have an importment association with nerve regeneration and reconstruction of synapse.
【CateGory Index】: R818
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