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《Chongqing Medical Journal》 2003-12
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The experimental investigation of the expression of CDK_2 in the culture of glomerular mesangial cells

ZHAO Jing hong,HUANG Wei lin,YANG Hui biao,et al (Department of Nephrology,Xinqiao Hospital,the Third Military Medical University,Chongqing 400037,China)  
Objective To investigate the regulation of interleukin 1 and interleukin 4 on the expression of cyclin dependent kinase CDK 2 in mesangial cells.Methods MTT incorporation,flow cytometry,and Western Blot were used to detect the effect of interleukin 1 on the proliferation and CDK 2 expression of rat glomerular mesangial cells cultured in vitro,as well as the effect of interleukin 4.Results Mesangial cell proliferation were promoted by interleukin 1,but the expression of CDK 2 was elevated at the same time.All of above were prevented by interleukin 4.Conclusion The promoted in CDK 2 levels may be important in determining the mesangial cells proliferative response to interleukin 1.The interleukin 1 induced mesangial cell proliferation inhibited by interleukin 4 is closely related to the expression of CDK 2.
【CateGory Index】: R692.6
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Chinese Journal Full-text Database 1 Hits
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