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《Chongqing Medical Journal》 2003-12
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Dectection of P53 and K-ras gene mutations in leukemia by oligonucleotide microarry

LI Yan 1,HUANG Jian 2,CHEN Jie ping1,et al. (1 Department of Tumor & Hematology,Southwest Hospital,the Third Military Medical University, Chongqing 400038,China;2.Yishengtang Biology Co.,Ltd.,Shenzhen,Guangdong 518026,China)  
Objective To discuss the role of P53 and K ras gene mutation in pathogenesis of leukemia.Method Fourty three leukemia samples were screened by the P53,K ras mutation detecting oligo microarry.Results Eight samples were found with P53 gene mutation and 4 had K ras gene mutation.Conclusion The P53 and K ras gene mutation play a certain role in the pathogenesis and progress of leukemia.There are both advantages and disadvantages in applying this new method.
【CateGory Index】: R733.7
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