Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chongqing Medical Journal》 2003-12
Add to Favorite Get Latest Update

Dectection of P53 and K-ras gene mutations in leukemia by oligonucleotide microarry

LI Yan 1,HUANG Jian 2,CHEN Jie ping1,et al. (1 Department of Tumor & Hematology,Southwest Hospital,the Third Military Medical University, Chongqing 400038,China;2.Yishengtang Biology Co.,Ltd.,Shenzhen,Guangdong 518026,China)  
Objective To discuss the role of P53 and K ras gene mutation in pathogenesis of leukemia.Method Fourty three leukemia samples were screened by the P53,K ras mutation detecting oligo microarry.Results Eight samples were found with P53 gene mutation and 4 had K ras gene mutation.Conclusion The P53 and K ras gene mutation play a certain role in the pathogenesis and progress of leukemia.There are both advantages and disadvantages in applying this new method.
【CateGory Index】: R733.7
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 6 Hits
1 BI Dan1, ZHOU Shu yun1, ZENG Mu sheng2, et al.1.Hematology Department, Nanfang Hospital,First Military Medical University, Guangzhou 510515, P.R. China2.Cancer Center,Sun Yat sen University of Medical Sciences,Guangzhou 510060,P.R.China;Functional detection of the p53 gene in chronic myeloid leukemia[J];CHINESE JOURNAL OF CANCER;1999-04
2 Tan yonghong ;Xian Guisheng ;Zhang Bechi;A STUDY OF THE c-k-ras ONCOGENE POINT MUTATION IN NON-SMALL CELL LUNG CANCER TISSUES[J];Chongqing Medical Journal;1997-01
3 XIAO Wen hua,LIU Wei wen,FANG Dian cun, et al. (Department of Oncology, Southwest Hospital,Chongqing 400038);Studies of pathogenetic elements of hepatocarcinoma from Chongqing by molecular epidemiology[J];Chongqing Medical Journal;2001-05
4 Li Xiaowen Zheng Hong Lian Jianhua Qi Hua You Wenfeng Song Guoying Chen Yuqing Department of Cellular Biology & Medical Genetics,Henan Medical University(Zhengzhou 450052);STUDY OF MUTATION OF MGMT AND p53 IN ACUTE NON-LYMPHOCYTIC LEUKEMIA[J];JOURNAL OF HEBEI MEDICAL UNIVERSITY;1999-05
5 Shi Feiman; Fan Wenhong(Institute of Basic Medical Sciences,Academy of Military Medical Sciences, Beijing 100850)DouHuanfu; GuYun; QueLianyong(Third Hospital of Beijing Medical University,Beijing 100083);A point mutation at codon 12 of the Ki- ras oncogene in myelodysplastic syndrome and acute nonlymphoblastic leukemia[J];BULLETIN OF THE ACADEMY OF MILITARY MEDICAL SCIENCES;1995-02
6 Lin Maofang, Liu Yanchun, Jin Jie.First Affiliated Hospital,Zhejiang Medical University, Hangzhou 310003;Study on MDM2 and p53 gene proteins expression on acute leukemic cells and its correlation with chemotherapeutic efficacy[J];CHINESE JOURNAL OF HEMATOLOGY;1998-07
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LI Xing-an, JIANG Ying (Medical School, Suzhou University, Suzhou 215007);Brain Cell Genes and Their Expression and Aging[J];Amino Acids & Biotic Resources;2003-01
2 CHEN Xuemei 1 XU Xiaoqun 2 ZHAO Jiandong 1 ZHU Li 1 XUE Aiying 1 ZHANG Daliang 1 ( 1Department of Otolaryngology,the Second Affiliated Hospital of Shandong University, Jinan,250033,China; 2Institute of Basic Medicine, Shandong Academy of Medical Science);The gene expression of Th1/Th2 cytokines and its role in hypopharyngeal carcinoma[J];Journal of Clinical Otorhinolaryngology;2004-06
3 Chen Feng,et al Department of Infection,the Affiliated Hospital of Luzhou Medical College;THE CONSTRUCTION OF RECOMBINANT ADENOVIRAL VACCINE VECTOR OF HBSAG[J];Journal of Luzhou Medical College;2007-04
4 BAI Hai-hua 1,HUANG Ya-feng 1,JIN Li-jie 2 (1.College of Clinical Medicine,Inner Mongolia University for Nationalities,Tongliao 028041,China; 2.College of Science and Engineering,Inner Mongolia University for Nationalities,Tongliao 028043,China);Study on the Foundation of Human Structural Gene and Its Applying[J];Journal of Inner Mongolia University for Nationalities(Natural Sciences,Quarterly);2002-05
5 LU Cheng,~1ZENG Shuilin,~1ZHANG Yinghua,et al (Maternity and Child Health Hospital Affiliated to Nanjing Medical University,Narying 210004;~1Neurbiology lnstitute of southeast university);Expressions of P21(WAF1),TGF-α and EGFR in pancreatic carcinoma and their relationship with nervous infiltration and metastasis[J];Journal of Nantong University(Medical Sciences);2006-01
6 Xu Yao,Yang Xiuying,Xing Jun,et al.Basic Medical Research Center,Tianjin Medical University,Tianjin 300070;Study on MSI and hMSH2 expression in gastric cancer[J];Chinese General Practice;2002-12
7 SUN Xiao-ju1,Wang Xu-kai1,JIA Lan-ling2.(1.School of Stomatology,China Medical University.Shenyang 110002;2.Tumour Research Institute of the First Affiliated Hospital,China Medical University.Shenyang 110001,Liaoning Province,China);The inhibitive effect of COX-2 inhibitor NS-398 on cancer cell growth of human tongue squamous cell carcinoma[J];Shanghai Journal of Stomatology;2006-01
8 GAO Xu-fang~(1,2),SHUAI Pei-qiang~3,RAO Chao-long~1,WEN Wei-hua~1,HENG Zhang-chang~1~△ (~1Department of Environmental Health,School of Huaxi Public Health,Sichuan University;~2 Chengdu Centre of Disease Control and Prevention;~3Inspection and Quarantine Technological Centre of Sichuan Enter-exit Inspection and Quarantine Bureau,Chengdu,Sichuan Province 610041,China);Research on the site of DNA lesion in k-ras gene induced by benzidine[J];Fudan University Journal of Medical Sciences;2007-01
9 HE Jing-song,LIN Mao-fang,CAI Zhen,et al(The First Affiliated Hospital,College of Medical Sciences, Zhejiang University,Hangzhou,310003,China)\;;Effect of p53 gene expression on apoptosis of K562 cellsinduced by ubenimex[J];Journal of Practical Oncology;2005-03
10 SUN Hui,NIU Rui-fang (Department of Experimental Tumor,Tianjin Cancer Hospital, Tianjin 300060,China);Analysis of gene differentially expressed in mice breast cancer by cDNA microarray[J];Journal of Tianjin Medical University;2002-04
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 PEI Li,CHENG Jie ping,LIANG Hou jie (1 Department of Hematology;2.Department of Oncology,Southwest Hospital, the Third Military Medical Univercity,Chongqing 400038,China);Induction of dendritic cells differentiation from cord blood CD34~+ cells expanded ex vivo[J];Chongqing Medical Journal;2004-05
2 PEI Li 1, CHEN Jie ping 1, LIANG Hou jie 2 ( 1Department of Hematology; 2Department of Oncology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Expressions and activation of JAK2 and STAT5 during the process of differentiation of human cord blood CD34~+ cells into dendritic cells[J];Acta Academiae Medicinae Militaris Tertiae;2004-11
3 CHEN Long 1, CHEN Jie ping 1, LIN Chen 2 ( 1Department of Hematology, Southwest Hospital, Third Military Medical University, Chongqing, 400038; 2Department of Cell Biology, Institute of Oncology, Chinese Academy of Medical Sciences, Beijing 100021, China);Effects of recombinant antisense c-myc adenovirus in induction of differentiation of HL-60 cells[J];Acta Academiae Medicinae Militaris Tertiae;2004-17
4 CHEN Jie-ping 1, Deborah Clarke 2, Constanze Bonifer 2 ( 1Department of Hematology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China; 2Molecular Medicine Unit, St. James's University Hospital, University of Leeds, Leeds LS9 7TF, UK);Roles of c-myb in haemopoietic differentiation and commitment of embryonic stem cells in vitro[J];Acta Academiae Medicinae Militaris Tertiae;2005-06
5 CHEN Long1, CHEN Jie-Ping1, LIN Chen2 1Department of Hematology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China, 2National Laboratory of Molecular Oncology, Cancer Institute, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100021, China;Effects of recombinant adenovirus encoding antisense c-myc on proliferation and cell cycle of HL-60 cells[J];Journal of The Fourth Military Medical University;2005-15
6 Qin Dabing, Chen Jieping, Wang Shenqi. Department of Hematology, Southwest Hospital, Third Military Medcial University, ChongQing 400038, China;Studies with an oligonucleotide microarray on the changes of gene expression related with NB4 apoptosis induced by arsenic trioxide[J];Medical Journal of Chinese People's Liberation Army;2007-05
7 CHEN Long, CHEN Jie-ping, LIN Chen,et al .(Department of Hematology, Southwest Hospital, Third Military Medical University, 400038, China);Transfection efficacy of recombinant adenovirus with Polycation on hematologic tumor cell lines in vitro[J];Medical Journal of National Defending Forces In Northwest China;2005-04
8 CHEN Long,CHEN Jie-ping,LIN Chen.(Department of Hematology,Southwest Hospital,Third Military(Medical) University,400038,China);Effect of recombinant antisense c-myc adenovirus on inducing granulocytic differentiation in HL-60 cells[J];Medical Journal of National Defending Forces in Northwest China;2006-01
9 LI Yan, HUANG Jian 2, CHEN Jie Ping, LIANG Hou Jie 1, WANG Sheng Qi 3 Department of Hematology and 1Department of Oncology, South West Hospital, Chongqing 400038, China; 2Yishengtang Biology Co. Ltd, Shenzhen 518026, China; 3Institute of Radiation Medicine of Academy of Military Medical Sciences, Beijing 100850, China;Identification bcr abl Fusion Gene in Leukemia Cells with Oligonucleotide Microarray[J];Journal of Experimental Hematology;2004-06
10 LIU Jing-Xia, CHEN Jie-Ping, TAN Wen1, LIN Dong-Xin1 Department of Hemotology, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China; 1Department of Etiology and Carcinogenesis, Cancer Institute & Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China;Association between Mthfr Gene Polymorphisms and Toxicity of HDMTX Chemotherapy in Acute Lymphocytic Leukemia[J];Journal of Experimental Hematology;2008-03
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 He Lizhen;Wang Shaoyuan;Guo Yongjun, et al(Fujian Imtitute of Hematology, Fuzhnu,350001);A STUDY ON P53 GENE IN LEUKEMIA[J];CHINESE JOURNAL OF HEMATOLOGY;1995-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved