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《Chongqing Medicine》 2006-01
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The effect of inhibitors of janus kinase/signal transducer and activator of transcription pathway in mediating level of TNF-α and IL-6 in rat cardial muscles during ischemia-reperfusion

SHEN Cheng,FAN Shi-zhi,CHEN Jian-ming,et al.(Chest Surgery Center of PLA,Daping Hospital,Third Military Medical University,Chongqing 400042,China)  
Objective To investigate the effect of inhibitors of janus kinase /signal transducer and activator of transcription(JAK/STAT) pathway in mediating level of TNF-α and IL-6 in rat cardial muscles during ischemiareperfusion.Methods Twenty-four male SD rats for isolated rat heart model were randomly divided into control group(n=6),ischemia-reperfusion group(n=6),AG490 treatment group(n=6),RMP treatment group(n=6).Level of TNF-α and IL-6 in the myocardium were measured by enzyme-linked immunosorbent assay(ELISA) system.Results TNF-α and IL-6 levels significantly increased after ischemia-reperfusion(P0.01).The levels of TNFα and IL-6 in AG490 or RMP treatment groups were significantly lower than that in ischemia-reperfusion group(P0.01).The levels of TNF-α and IL-6 in AG490 or RMP treatment groups were little higher than that in control group,but there were no significantly changes between the two groups(P0.05).Conclusion The result suggest that myocardial ischemia-reperfusion can result in intensive activation of TNF-α and IL-6.Early treatment with inhibitors to JAK/STAT pathway might be benefit for attenuation of myocardial injury induced by ischemia-reperfusion and subsequent acute inflammatory response.
【CateGory Index】: R541
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